Results 31 to 40 of about 2,403,940 (310)

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

Fraud Pemerintah Aceh: Apa Penyebabnya?

Jurnal Kajian Akuntansi, 2022
The purpose of this research is to find out and also analyze the tendency for fraud to occur in the government sector, the tendency for fraud to occur will be carried out by testing and analyzing the driving force of internal control, then enforcement of
Fariz Munadi, Darwanis Darwanis, Ridwan Ibrahim, Fifi Yusmita   +3 more
doaj   +1 more source

Virulence- and signaling-associated genes display a preference for long 3′UTRs during rice infection and metabolic stress in the rice blast fungus [PDF]

, 2019
Generation of mRNA isoforms by alternative polyadenylation (APA) and their involvement in regulation of fungal cellular processes, including virulence, remains elusive.
Demuez, Marie, Marconi, Marco, Ortega-Campayo, Víctor, Rodríguez-Romero, Julio, Sesma, Ane, Wilkinson, Mark D.   +5 more
core   +1 more source

NUDT21 Drives T‐Cell Acute Lymphoblastic Leukemia Through Dual Regulation of Alternative Polyadenylation and Transcriptional Activation

Advanced Science, EarlyView.
In summary, our study defines a coordinated oncogenic model in which NUDT21 integrates alternative polyadenylation–dependent UBE2D3 stabilization and transcriptional activation to sustain MYC‐driven T‐ALL cell survival, thereby establishing NUDT21 as a central regulatory node and a promising therapeutic target.
Conglian Qiu, Jianwei Wang, Zhiheng Li, Qi Ji, Hui Zhang, Qinyi Zhang, Senlin Zhang, Juanjuan Yu, Yanfang Tao, Yijun Wu, Chunxia Shi, Zong Zai, Zimu Zhang, Yizhen Li, Zhenjiang Bai, Shaoyan Hu, Jian Pan, Yang Yang, Shuiyan Wu   +18 more
wiley   +1 more source

ALGUNAS CONSIDERACIONES SOBRE LOS ACUERDOS PREVIOS DE VALORACIÓN DE PRECIOS DE TRANSFERENCIA, APAS, EN EL ORDENAMIENTO TRIBUTARIO ESPAÑOL [PDF]

Crónica Tributaria, 2011
La principal finalidad del artículo es describir y comentar la nueva regulación sobre los Acuerdos Previos de Valoración en materia de precios de transferencia en España o APA, tal y como se norman en el artículo 16.7 TRLIS y en el Reglamento del ...
Domingo Carbajo Vasco
doaj  

Unions and Upward Mobility for Asian Pacific American Workers [PDF]

, 2009
Asian Pacific American (APA) workers are, with Latinos, the fastest growing group in the U.S. workforce and in organized labor. Since the late 1980s, APA workers have seen their representation in the ranks of U.S.
Hye Jin Rho, John Schmitt, Nicole Woo
core  

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source

The Effect of 8-week Aerobic Physical Activity on Hs-CRP and Blood Pressure of the Shift Workers of Sarir Plast Industrial Group in Dezful [PDF]

Journal of Advanced Biomedical Sciences, 2019
Background &Objective: Shift work can be a factor in inflammation, hypertension and cardiovascular diseases. The purpose of the present study was to evaluate the effect of 8-week aerobic physical activity on Hs-CRP and blood pressure of the shift workers
Aboutaleb Bagheri, Nader Shakeri, Hojatollah Nik Bakht   +2 more
doaj  

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source

Molecular Design and Interfacial Functions of Self‐Assembled Monolayers for Perovskite and Tandem Solar Cells

Advanced Energy Materials, EarlyView.
We identify two decisive levers for SAM interfaces: molecular design (carboxylic acid‐based, phosphonic acid, other anchoring chemistries, and polymeric SAMs) and mixing routes (co‐assembly, in situ assembly, pre‐ and post‐treatment). Coordinated tuning of headgroups and assembly pathways optimises energy alignment and film formation, suppresses ...
Jiaxu Zhang, Bochun Kang, Feng Yan
wiley   +1 more source