Results 31 to 40 of about 35,007 (144)
Model‐Informed Drug Development Applications and Opportunities in mRNA‐LNP Therapeutics
Clinical Pharmacology &Therapeutics, EarlyView.The utilization of lipid nanoparticles (LNP) for encapsulating mRNA has revolutionized the field of therapeutics, enabling the rapid development of COVID‐19 vaccines and cancer vaccines. However, the clinical development of mRNA‐LNP therapeutics faces numerous challenges due to their complex mechanisms of action and limited clinical experience.
Jiawei Zhou +6 more
wiley +1 more source
Association of Apgar scores with death and neurologic disability [PDF]
, 2009 Apgar score was devised with the aim to standardize the assessment of newborns. It has been used worldwide to evaluate infants’ condition immediately after birth, to determine their need for resuscitation, and to evaluate the effectiveness of ...
Ehrenstein, Vera
core +2 more sources
Clinical Pharmacology &Therapeutics, EarlyView.Over 10 million children in the world have epilepsy, with an unknown cause in half of the cases. The gut microbiome has been associated with various neurological disorders, and certain drugs greatly disturb the microbiome. Our aim was to study the association of prenatal and childhood exposure (before the age of two) to antibiotics, proton pump ...
Unnur Gudnadottir +4 more
wiley +1 more source
Biology and Management of Male‐Bodied Athletes in Elite Female Sports
Drug Testing and Analysis, EarlyView.Graphical representation of the relationships of transgender and XY DSDF as male‐bodied athletes along the binary dimensions of biological sex. ABSTRACT The physical advantages in elite power sports that allow men to surpass women are derived from the experience of male puberty.
David J. Handelsman, Stéphane Bermon
wiley +1 more source
Epilepsia Open, EarlyView.Abstract Objective Ketogenic diet therapies (KDTs) are increasingly used as a treatment for people with epilepsy of childbearing potential (PWECP) and glucose transporter type 1 deficiency syndrome (Glut1DS). The aim of this study was to collect information on clinical experience with KDT during pregnancy and lactation in these populations.
Kelly Faltersack +12 more
wiley +1 more source
International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 31-37, April 2025.Abstract Spontaneous hemoperitoneum in pregnancy (SHIP) is defined as sudden, nontraumatic intraperitoneal bleeding that occurs during pregnancy or up to 42 days postpartum. The incidence ranges between 4 and 4.9 per 100 000 births. Although seen rarely, it is associated with perinatal morbidity and mortality due to maternal hemodynamic instability ...
Shamsi Mehdiyev +3 more
wiley +1 more source
International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 408-420, April 2025.Abstract Objective Birth asphyxia is one of the leading causes of death for neonates worldwide. Lack of an objective cost effective test to predict poor newborn outcomes at birth affects the ability to respond appropriately. This study determined predictive values of umbilical cord arterial lactate in relation to adverse neonatal outcomes. Methods This
Elizabeth Ayebare +7 more
wiley +1 more source
Examination of Systole/Diastole Ratio of Umbilical Artery in the third Trimester Gestational Pregnancy and its Correlation with Lactate Acid Level in Fetal Cord [PDF]
, 2020 BACKGROUND: Fetal distress is a serious complication of perinatal infants and refers to fetal hypoxia in the uterus and asphyxia immediately after the baby is born.
Lumbanraja, Sarma Nursani +2 more
core +2 more sources
Optimal timing for induction of labor in normotensive women: A retrospective cohort study
International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 365-371, April 2025.Abstract Objective Labor induction is offered to reduce the risk of stillbirth at late term (41+0 to 41+6) but earlier induction in normotensive singleton pregnancies is supported by weak evidence. The aim of the present study was to investigate the optimal timing for induction in normotensive women.
Jóhanna Gunnarsdóttir +3 more
wiley +1 more source