Results 81 to 90 of about 43,470 (269)

Tranexamic acid dosing in pediatric trauma: Dose simulation based on population pharmacokinetic modeling in adult trauma patients

Transfusion, EarlyView.
Abstract Background Trauma is the most common cause of death in children >1 year of age, with hemorrhage being the most common preventable cause of death after injury. Antifibrinolytics like tranexamic acid (TXA) are a key aspect of trauma management in children, but optimal dosing remains unknown.
Gideon Stitt, Kevin Downes, Athena Zuppa, Christine Leeper, Kevin Watt, Philip Spinella   +5 more
wiley   +1 more source

Optimization of human mesenchymal stem cell manufacturing: the effects of animal/xeno-free media. [PDF]

, 2015
Due to their immunosuppressive properties, mesenchymal stem cells (MSC) have been evaluated for the treatment of immunological diseases. However, the animal-derived growth supplements utilized for MSC manufacturing may lead to clinical complications ...
Hommes, Daniel W, Lacey, Precious N, Manansala, Aida-Rae, Oikonomopoulos, Angelos, Tomakili, Tamera A, van Deen, Welmoed K, Ziman, Alyssa   +6 more
core   +3 more sources

An audit of platelet transfusions at a tertiary care center: New opportunities for patient blood management with the 2025 AABB/ICTMG platelet guidelines

Transfusion, EarlyView.
Abstract Background Platelet transfusions are an important tool to prevent and stop bleeding. Thresholds for pretransfusion platelet counts have been studied in various patient populations, yielding evidence‐based guidelines. The Association for the Advancement of Blood and Biotherapies (AABB) collaborated with the International Collaboration for ...
Rylee Yakymi, Claudia S. Cohn
wiley   +1 more source

Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society [PDF]

, 2014
AIMS: Homozygous familial hypercholesterolaemia (HoFH) is a rare life-threatening condition characterized by markedly elevated circulating levels of low-density lipoprotein cholesterol (LDL-C) and accelerated, premature atherosclerotic cardiovascular ...
Averna, M, AVERNA, Maurizio, Boileau, C, Boileau, C, Boren, J, Boren, J, Bruckert, E, Bruckert, E, Catapano, A, Catapano, A, Chapman, M, Chapman, M, Chapman, M, Cuchel, M, Cuchel, M, Defesche, J, Defesche, J, Descamps, O, Descamps, O, Ginsberg, H, Ginsberg, H, Ginsberg, H, Hegele, R, Hegele, R, Hovingh, G, Hovingh, G, Humphries, S, Humphries, S, Kovanen, P, Kovanen, P, Kuivenhoven, J, Kuivenhoven, J, Masana, L, Masana, L, Nordestgaard, B, Nordestgaard, B, Pajukanta, P, Pajukanta, P, Parhofer, K, Parhofer, K, Raal, F, Raal, F, Ray, K, Ray, K, Santos, R, Santos, R, Stalenhoef, A, Stalenhoef, A, Steinhagen Thiessen, E, Steinhagen Thiessen, E, Stroes, E, Stroes, E, Taskinen, M, Taskinen, M, Tybjaerg Hansen, A, Tybjaerg Hansen, A, Watts, G, Watts, G, Wiegman, A, Wiegman, A, Wiklund, O, Wiklund, O.   +61 more
core   +1 more source

Safety and efficacy of combined heparin/citrate anticoagulation for cell therapy collections in healthy adult allogeneic donors

Transfusion, EarlyView.
Abstract Background Reports on the safety and efficacy of combination heparin and citrate anticoagulation with cell therapy collections in adults are limited. There are no reports on the use of this combination in healthy allogeneic adult donors undergoing cell therapy collection. This retrospective analysis is the first study to examine its safety and
Jiahao Zhang, Minlin Wu, Sabrina Racine‐Brzostek, Sarah Shayo, Karina Yazdanbakhsh, Stephanie Dormesy, Patricia A. Shi   +6 more
wiley   +1 more source

Pharmacokinetic analysis after implantation of everolimus-eluting self-expanding stents in the peripheral vasculature [PDF]

, 2012
Background: A novel self-expanding drug-eluting stent was designed to release everolimus 225 mu g/cm(2) to prevent restenosis following peripheral arterial intervention.
Hausegger, Klaus A, Koppensteiner, Renate, Lammer, Johannes, Mellon, Rajeev M, Scheinert, Dierk, Schroë, Herman, Schwartz, Lewis B, Vermassen, Frank   +7 more
core   +2 more sources

Novel method for trend change detection and hypothesis generation in hemovigilance: A transfusion‐related immunomodulation and blood production changes study

Transfusion, EarlyView.
Abstract Background Immunomodulatory consequences of transfusion, known as transfusion‐related immune modulation (TRIM), impact patients but are not captured by hemovigilance systems. This study's objective is to explore TRIM impacts of production changes made by the blood supplier. Methods We included all transfused and non‐transfused adult inpatients
S. Ning, N. Li, Y. Liu, D. Kim, J. P. Acker, D. Arnold, M. Hadzi‐Tosev, C. Hillis, A. Kauffman, K. J. Lucier, P. C. Liaw, B. Rochwerg, S. Syed, G. Travis, M. Zeller, N. M. Heddle   +15 more
wiley   +1 more source

Longitudinal metabolomics study of phosphate‐adenine‐guanosine‐glucose‐saline‐mannitol stored red blood cells

Transfusion, EarlyView.
Abstract Background The storage of red blood cells (RBCs) is essential for transfusion but leads to storage lesions that compromise RBC quality and increase the risk of transfusion‐related adverse effects, including allergic transfusion reactions (ATRs). Understanding storage‐induced metabolic change is crucial for enhancing transfusion safety.
Gürkan Bal, Maia Dzamashvili, Zhuoran Li, Magda Babina, Nidal Toman, Abdulgabar Salama   +5 more
wiley   +1 more source

Identification of IV fluid contamination in complete blood counts and subsequent unnecessary red blood cell transfusions using artificial intelligence

Transfusion, EarlyView.
Abstract Background Specimens contaminated with intravenous (IV) fluids can lead to considerable measurement errors in complete blood counts (CBCs), posing challenges for laboratory operations and clinical decision‐making. There is no gold‐standard method for retrospectively identifying these events, making it difficult to target quality improvement ...
Carly Maucione, Nathan McLamb, Mark A. Zaydman, Lauren N. Pearson, Ryan A. Metcalf, Nicholas C. Spies   +5 more
wiley   +1 more source

Acrodermatitis continua of Hallopeau: clinical perspectives. [PDF]

, 2019
Acrodermatitis continua of Hallopeau (ACH) is a rare, sterile pustular eruption of one or more digits. The condition presents with tender pustules and underlying erythema on the tip of a digit, more frequently arising on a finger than a toe.
Beck, Kristen M, Bhutani, Tina, Liao, Wilson, Ly, Karen, Smith, Mary Patricia, Thibodeaux, Quinn   +5 more
core