Results 81 to 90 of about 36,968 (256)

Apremilast in Japanese patients with palmoplantar pustulosis: A randomized, Phase 3 trial

Journal of the European Academy of Dermatology and Venereology, EarlyView.
In this Phase 3 trial of Japanese patients with moderate to severe PPP (NCT05174065), significantly more patients achieved PPPASI‐50 at Week 16 with apremilast versus placebo. Patient‐reported outcomes, including pruritus and pain/discomfort, also showed significantly greater decreases at Week 16 with apremilast versus placebo.
Tadashi Terui, Yukari Okubo, Satomi Kobayashi, Akimichi Morita, Shinichi Imafuku, Yayoi Tada, Masatoshi Abe, Bruce Strober, Melinda Gooderham, Wendy Zhang, Junichiro Shimauchi, Masafumi Yaguchi, Takeshi Kimura, Ryuichi Ogawa, Hamid Amouzadeh, Masamoto Murakami   +15 more
wiley   +1 more source

Severe hyperlipoproteinemia(a) as a factor of rapidly progressive coronary artery disease in a young woman with heterozygous familial hypercholesterolemia

Российский кардиологический журнал, 2019
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U. V. Chubykina, O. I. Afanasieva, N. T. Khachatryan, N. G. Kukava, V. P. Vasiliev, M. V. Ezhov   +5 more
doaj   +1 more source

Apoptosis kinetics of purified and PBMC‐associated lymphocytes after photopheresis‐like 8‐methoxypsolaren/UVA treatment

Photochemistry and Photobiology, EarlyView.
Extracorporeal photopheresis (ECP) induces apoptosis in circulating immune cells, but its kinetics vary slightly depending on the cell type. We compared the progression of apoptosis in PBMCs versus highly purified T cells exposed to 8‐methoxypsoralen and ultraviolet A.
Carlos Agustin Villegas‐Valverde, Imilla Casado Hernandez, Yandy Marx Castillo‐Aleman, Gisela Maria Suarez‐Formigo, Amar Riaz, Antonio Alfonso Bencomo‐Hernandez, Yendry Ventura‐Carmenate   +6 more
wiley   +1 more source

Hepatitis E virus screening in Irish blood donors: Seven years of individual donation nucleic acid testing reveals a frequent blood donor infection—but what is the risk?

Transfusion Medicine, EarlyView.
Abstract Background Screening blood donations for HEV RNA mitigates the risk of transfusion‐transmitted HEV infection (TT‐HEV), a recognised blood safety issue in Europe. This study reports the findings of government‐funded HEV RNA blood donation screening 2016–2022 and includes an estimate of residual risk. Method Donation samples were universally and
Niamh O'Flaherty, Marice Mullarkey, Lisa Burke, Pádraig Williams, Jonathan Dean, Jola Szulc, Allison Waters   +6 more
wiley   +1 more source

Impact of Preanalytical Sample Preparation on the Recovery Rate of Cryopreserved Allogeneic Hematopoietic Stem Cells. [PDF]

Eur J Haematol
ABSTRACT Introduction Cryopreservation of peripheral‐blood‐derived hematopoietic stem and progenitor cells (PBSCs) has been used for decades, primarily for autologous transplantation. Now, in the era of new cellular therapies, the cryopreservation of allogeneic PBSCs may also become relevant.
Blüm P, Glas C, Bieback K, Kayser S, Klüter H, Wuchter P.   +5 more
europepmc   +2 more sources

Donor retention and return patterns in Saudi Arabia: Implications for blood safety and supply stability

Transfusion Medicine, EarlyView.
Abstract Background Sustaining a safe and sufficient blood supply requires not only recruiting first‐time donors but also retaining them over time. In Saudi Arabia, donor retention remains poorly understood, with limited data on return behavior, demographic influences, and temporal trends.
Wajnat A. Tounsi, Bushra S. Almalki
wiley   +1 more source

Pregnancy in a Woman with Homozygous Familial Hypercholesterolemia Not on Low-Density Lipoprotein Apheresis [PDF]

, 2014
Pregnancy in women with homozygous familial hypercholesterolemia (FH) has been rarely reported and might pose risks on the mother and her fetus. Although most reported cases remained on low-density lipoprotein (LDL) apheresis, there are no clear ...
Fahed, Akl C., Nassar, Anwar H.
core   +1 more source

Monitoring of haematopoietic stem cell mobilization by targeted DNA methylation analysis for the British Journal of Haematology

British Journal of Haematology, EarlyView.
Wouter H. G. Hubens, Anke Diehlmann, Patrick Wuchter, Wolfgang Wagner   +3 more
wiley   +1 more source

What is the best approach to blood transfusion in sickle cell disease? A scientometric analysis and literature review

Transfusion Medicine, EarlyView.
Abstract Background Blood transfusion remains a cornerstone in the management of sickle cell disease (SCD); however, it is frequently complicated by red cell alloimmunisation. A significant debate persists within the scientific community regarding the optimal strategy to mitigate this risk: the traditional, pragmatic approach of serologic phenotyping ...
Christiane Ruffato Carminati, Lucas Fernandes Ananias, Saulo Fernando Moreira da Silva, Anna Cecília Dias Maciel Carneiro, Helio Moraes de Souza, Sarah Cristina Sato Vaz Tanaka, Fernanda Bernadelli De Vito   +6 more
wiley   +1 more source

Clinical experience of lomitapide therapy in patients with homozygous familial hypercholesterolaemia [PDF]

, 2014
The microsomal triglyceride transfer protein (MTP) inhibitor lomitapide is a licenced adjunct to a low-fat diet and other lipid-lowering medication, with or without low-density lipoprotein apheresis, for the treatment of adults with homozygous familial ...
AVERNA, Maurizio, Blom, DJ, Cuchel, M
core   +1 more source