Results 111 to 120 of about 3,368 (278)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

open access: yesFEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Priapism: A review

open access: yesInternational Journal of Medicine and Health Development, 2003
Aim: To explore the aetiological factors, pathogenesis and management of priapism and highlight its peculiar features in Nigerians. Materials & Methods: A literature search was carried out using MEDLINE, these were reviewed in line with the aims for ...
Fred O Ugwumba, Aloy E Aghaji
doaj  

Role of Herbaria in the development of microregions [PDF]

open access: yes, 2015
Jelen dolgozatban olyan modellt dolgoztam ki és mutattam be, amely lehetőséget ad az ember alapvető szükségleteinek kielégítésén keresztül az egészség fenntartására és szükség esetén helyreállítására.
Kmeth, Sándor
core  

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

open access: yesFEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo   +7 more
wiley   +1 more source

Studying the Body in Rastafari Rituals: Spirituality, Embodiment and Ethnographic Knowledge [PDF]

open access: yes, 2016
Rastafari spirituality is a nonsecular science that considers how various energies and powers influence socio-ecological systems. Rastafari people follow a number of spiritual prescriptions related to the body, including smoking, meditating, growing ...
Waldstein, Anna
core  

Network Localization of Fatigue in Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Fatigue is among the most common symptoms and one of the main factors determining the quality of life in multiple sclerosis (MS). However, the neurobiological mechanisms underlying fatigue are not fully understood. Here we studied lesion locations and their connections in individuals with MS, aiming to identify brain networks ...
Olli Likitalo   +12 more
wiley   +1 more source

Frailty Exacerbates Disability in Progressive Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks   +10 more
wiley   +1 more source

Erectile dysfunction in copper and cobalt miners: a cross-sectional study in the former Katanga province, Democratic Republic of the Congo. [PDF]

open access: yesSex Med, 2023
Musa Obadia P   +11 more
europepmc   +1 more source

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