Results 111 to 120 of about 17,169 (224)

The evolutionary history of Plasmodium falciparum from mitochondrial and apicoplast genomes of China-Myanmar border isolates

Parasites & Vectors
The frequent communication between African and Southeast Asian (SEA) countries has led to the risk of imported malaria cases in the China-Myanmar border (CMB) region.
Yini Tian, Run Ye, Dongmei Zhang, Yilong Zhang   +3 more
semanticscholar   +1 more source

Small molecule inhibition of apicomplexan FtsH1 disrupts plastid biogenesis in human pathogens

eLife, 2017
The malaria parasite Plasmodium falciparum and related apicomplexan pathogens contain an essential plastid organelle, the apicoplast, which is a key anti-parasitic target. Derived from secondary endosymbiosis, the apicoplast depends on novel, but largely
Katherine Amberg-Johnson, Sanjay B Hari, Suresh M Ganesan, Hernan A Lorenzi, Robert T Sauer, Jacquin C Niles, Ellen Yeh   +6 more
doaj   +1 more source

The apicoplast of Plasmodium falciparum is translationally active

, 2005
Summary: Apicoplast, the plastid-like organelle of apicomplexan parasites, has generated interest as a putative drug target. Although transcripts for genes encoded by the 35 kb circular plastid DNA have been detected, the actual presence of their protein
Chaubey, Sushma, Singh, Divya, Kumar, Ambrish, Habib, Saman   +3 more
core   +1 more source

Disruption of the Suf pathway leads to apicoplast loss.

, 2013
The Isc pathway is located in the mitochondrion while the Suf pathway is located in the apicoplast. The exclusive division of the two pathways between the two endosymbiont organelles suggests that the FeS-dependent proteins the apicoplast rely solely on ...
Krista A. Matthews (463664), Teegan A. Dellibovi-Ragheb (399303), Sean T. Prigge (370088), Jolyn E. Gisselberg (399304), Gundula Bosch (463665)   +4 more
core   +1 more source

Toxoplasma gondii devoid of an apicoplast - Addition

This is an addition to a previously published dataset termed 'Toxoplasma gondii devoid of an apicoplast', accessible under 10.26037/yareta:kc446nwxifbvtb5z7l2f6tayga This dataset is associated with a study describing the investigation of Toxoplasma ...
von Rohr, Olivier, Bonavoglia, Alessandro, Koszti, Szilamer, Chen, Min, Peng, Hongjuan, Soldati-Favre, Dominique, Kloehn, Joachim   +6 more
core   +1 more source

Azithromycin disrupts apicoplast biogenesis in replicating and dormant liver stages of the relapsing malaria parasites Plasmodium vivax and P. cynomolgi.

International Journal of Antimicrobial Agents
The control and elimination of malaria caused by Plasmodium vivax is hampered by the threat of relapse infection resulting from the activation of dormant hepatic hypnozoites.
Nadia Amanzougaghene, Shahin Tajeri, J. Franetich, Kutub Ashraf, V. Soulard, Pierre Bigeard, C. O. Guindo, Camille Bouillier, Julien Lemaitre, F. Relouzat, Roger Legrand, C. Kocken, A. Zeeman, W. Roobsoong, J. Sattabongkot, Zhaoqing Yang, Georges Snounou, Dominique Mazier   +17 more
semanticscholar   +1 more source

A Plasmodium apicoplast-targeted unique exonuclease/FEN exhibits interspecies functional differences attributable to an insertion that alters DNA-binding

Nucleic Acids Research
The human malaria parasite Plasmodium falciparum genome is among the most A + T rich, with low complexity regions (LCRs) inserted in coding sequences including those for proteins targeted to its essential relict plastid (apicoplast).
Tribeni Chatterjee, Anupama Tiwari, Ritika Gupta, Himadri Shukla, Aastha Varshney, Satish Mishra, Saman Habib   +6 more
semanticscholar   +1 more source

Deep-learning protein structure predictions suggest likely molecular functions for three uncharacterised polytopic membrane proteins from the P. falciparum apicoplast

bioRxiv
Malaria is a burdensome disease to humanity caused chiefly by the still poorly understood parasite genus Plasmodium. Much of the pathogenic success of these and other related parasites is due to the presence of the apicoplast, a comparatively poorly ...
D. L. Murphy, Shahram Mesdaghi, Filomeno Sánchez Rodríguez, A. Simpkin, Luc Elliott, Daniel J. Rigden   +5 more
semanticscholar   +1 more source

Molecular docking, MD simulation, and MMGBSA-binding free energy estimation study identify antibiotic analogs as potential antimalarials targeting housekeeping proteins of Plasmodium falciparum apicoplast

Molecular Simulation
Plasmodium falciparum exclusively harbours a non-photosynthetic plastid-like organelle called ‘apicoplast,’ crucial for survival. The apicoplast genome resembles chloroplasts, albeit much reduced at 35 kb. The housekeeping functions of the apicoplast are
B. Naik, Dhaneswar Prusty
semanticscholar   +1 more source

Cell cycle-regulated transcription factor AP2XII-9 is a key activator for asexual division and apicoplast inheritance in Toxoplasma gondii tachyzoite

mBio
Toxoplasma gondii is an intracellular parasitic protozoan that poses a significant risk to the fetus carried by a pregnant woman or to immunocompromised individuals. T.
Yuehong Shi, Xuan Li, Yingying Xue, Dandan Hu, Xingju Song   +4 more
semanticscholar   +1 more source