Results 1 to 10 of about 235,862 (234)

Disease-specific epigenetic deregulation of enhancers, transposons, and polycomb targets in acute promyelocytic leukemia [PDF]

open access: yesGenome Medicine
Background Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML), characterized by a fusion between the PML and RARA genes and by a block in the myeloid maturation at the promyelocytic stage.
Xiangfu Zhong   +6 more
doaj   +2 more sources

A comparative study of anti-leukemic effects of kaempferol and epigallocatechin-3-gallate (EGCG) on human leukemia HL-60 cells [PDF]

open access: yesAvicenna Journal of Phytomedicine, 2021
Objective: Acute promyelocytic leukemia (APL) is among the most threatening hematological malignant cancers. Defects in cell growth and apoptotic pathways lead to the pathogenesis of the disease as well as its resistance to therapy; therefore, it is a ...
Mohammad Hassan Jokar   +2 more
doaj   +1 more source

Energetic Electrons Near Europa From Juno JEDI Data

open access: yesGeophysical Research Letters, 2023
Optical remote sensing observations have suggested that the top layer of Europa's icy surface is heavily affected by external weathering agents. To model and understand these effects, it is necessary to characterize the environment as fully as possible ...
C. Paranicas   +10 more
doaj   +1 more source

Energetic Charged Particle Fluxes Relevant to Ganymede's Polar Region

open access: yesGeophysical Research Letters, 2022
The JEDI instrument made measurements of energetic charged particles near Ganymede during a close encounter with that moon. Here we find ion flux levels are similar close to Ganymede itself but outside its magnetosphere and on near wake and open field ...
C. Paranicas   +10 more
doaj   +1 more source

Downregulation of hsa-miR-4328 and target gene prediction in Acute Promyelocytic Leukemia

open access: yesRomanian Journal of Laboratory Medicine, 2022
Introduction: Acute promyelocytic leukemia (APL) is defined by the PML-RARA fusion gene. APL treatment can have significant side effects, therefore the development of optimal therapeutic options is crucial.
Lupu Onda T.   +7 more
doaj   +1 more source

Acute promyelocytic leukemia (APL): a review of the literature

open access: yesOncoTarget, 2020
Acute Promyelocytic Leukemia (APL) is characterized by a block in differentiation where leukemic cells are halted at the promyelocyte stage. A characteristic balanced chromosomal translocation between chromosomes 15 and 17 t (15;17) (q24; q21) is seen in
J. Jimenez   +3 more
semanticscholar   +1 more source

A phase 2 study of ATRA, arsenic trioxide, and gemtuzumab ozogamicin in patients with high-risk APL (SWOG 0535).

open access: yesBlood Advances, 2020
High-risk acute promyelocytic leukemia (APL) remains a therapeutic challenge, with higher associated rates of early mortality and relapse than standard-risk APL.
J. Lancet   +9 more
semanticscholar   +1 more source

Strategic process in local productive arrangements: the challenge of cooperation

open access: yesRevista Eletrônica de Ciência Administrativa, 2020
The main objective of this study was to analyze how the strategic process occurs in a Local Productive Arrangement (APL) of software development. To this end, we examined the influence of rational and non-rational aspects such as sensemaking, creativity,
Carla Cristina Silva, Lucilaine Pascuci
doaj   +1 more source

Listener-Position and Orientation Dependency of Auditory Perception in an Enclosed Space: Elicitation of Salient Attributes

open access: yesApplied Sciences, 2021
This paper presents a subjective study conducted on the perception of auditory attributes depending on listener position and head orientation in an enclosed space.
Bogdan Ioan Băcilă, Hyunkook Lee
doaj   +1 more source

Average propagation length analysis for the change trend of China’s construction industry chain

open access: yesJournal of Asian Architecture and Building Engineering, 2022
The sustainable development of the construction industry in China requires in-depth analysis of the industrial chain related to the construction industry and the transformation of its production mode. Through analysis of input–output tables over years of
Zhao Yang   +3 more
doaj   +1 more source

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