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Acute promyelocytic leukemia (APL) is associated with reciprocal and balanced chromosomal translocations always involving the Retinoic Acid Receptor alpha (RARalpha) gene on chromosome 17 and variable partner genes (X genes) on distinct chromosomes. RARalpha fuses to the PML gene in the vast majority of APL cases, and in a few cases to the PLZF, NPM ...
Francesco Piazza, Pier Paolo Pandolfi
exaly +4 more sources
Energetic Electrons Near Europa From Juno JEDI Data
Optical remote sensing observations have suggested that the top layer of Europa's icy surface is heavily affected by external weathering agents. To model and understand these effects, it is necessary to characterize the environment as fully as possible ...
C. Paranicas +10 more
doaj +1 more source
Energetic Charged Particle Fluxes Relevant to Ganymede's Polar Region
The JEDI instrument made measurements of energetic charged particles near Ganymede during a close encounter with that moon. Here we find ion flux levels are similar close to Ganymede itself but outside its magnetosphere and on near wake and open field ...
C. Paranicas +10 more
doaj +1 more source
A comparative study of anti-leukemic effects of kaempferol and epigallocatechin-3-gallate (EGCG) on human leukemia HL-60 cells [PDF]
Objective: Acute promyelocytic leukemia (APL) is among the most threatening hematological malignant cancers. Defects in cell growth and apoptotic pathways lead to the pathogenesis of the disease as well as its resistance to therapy; therefore, it is a ...
Mohammad Hassan Jokar +2 more
doaj +1 more source
Downregulation of hsa-miR-4328 and target gene prediction in Acute Promyelocytic Leukemia
Introduction: Acute promyelocytic leukemia (APL) is defined by the PML-RARA fusion gene. APL treatment can have significant side effects, therefore the development of optimal therapeutic options is crucial.
Lupu Onda T. +7 more
doaj +1 more source
Strategic process in local productive arrangements: the challenge of cooperation
The main objective of this study was to analyze how the strategic process occurs in a Local Productive Arrangement (APL) of software development. To this end, we examined the influence of rational and non-rational aspects such as sensemaking, creativity,
Carla Cristina Silva, Lucilaine Pascuci
doaj +1 more source
Background: Acute promyelocytic leukemia is a peculiar disease with few studies that have investigated the prognostic significance of PML/RARA transcript level at diagnosis. Patients and methods: This retrospective study included all cases diagnosed with
Eman O. Rasekh +2 more
doaj +1 more source
A Development of a Human Cranial Bone Surrogate for Impact Studies
In order to replicate the fracture behavior of the intact human skull under impact it becomes necessary to develop a material having the mechanical properties of cranial bone.
Jack C Roberts +7 more
doaj +1 more source
APL programming without tears: it is time for a change [PDF]
Naeve P, Strohmeier B, Wolf P. APL programming without tears: it is time for a change. APL Quote Quad. 1993;24(1):185-189.To overcome the unreadability of traditional APL-code Knuth's idea of literate programming is adapted to APL.
Naeve, Peter +5 more
core +1 more source
This paper presents a subjective study conducted on the perception of auditory attributes depending on listener position and head orientation in an enclosed space.
Bogdan Ioan Băcilă, Hyunkook Lee
doaj +1 more source

