Results 61 to 70 of about 235,874 (246)

The agent programming language meta-APL [PDF]

, 2011
. We describe a novel agent programming language, Meta-APL, and give its operational semantics. Meta-APL allows both agent programs and their associated deliberation strategy to be encoded in the same programming language.
Alechina, Natasha, Doan, Trang, Logan, Brian   +2 more
core   +1 more source

Molecular methods for genomic analyses of variant PML-RARA or other RARA-related chromosomal translocations in acute promyelocytic leukemia [PDF]

, 2012
TO THE EDITOR: We read an interesting paper by Palta et al. in a recent issue of the Korean Journal of Hematology titled, "ZBTB16-RARA variant of acute promyelocytic leukemia with tuberculosis: a case report and review of literature" [1].
Kim, Min Jin, Marschalek, Rolf, Meyer, Claus, Park, Tae Sung, Yang, John Jeongseok   +4 more
core   +1 more source

Xanthatin Targets CISD1 to Drive Ferroptosis and Mitophagy as a Dual Anticancer Strategy in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer has a poor prognosis. Xanthatin directly targets and degrades CISD1, triggering ferroptosis through iron dysregulation. The concurrently activated mitophagy synergistically amplifies ferroptotic cell death. Xanthatin also demonstrates potent in vivo anti‐tumor efficacy with minimal toxicity, highlighting its therapeutic ...
Qinwen Liu, Haojie Chen, Xiang Li, Jingxin Liu, Yiwen Li, Zhenyi Shi, Shenshen Guo, Qingfeng Du, Aiping Lu, Daogang Guan   +9 more
wiley   +1 more source

Effects of vaccination with altered peptide ligand on chronic pain in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis [PDF]

, 2013
Neuropathic pain is a chronic symptom of multiple sclerosis (MS) and affects nearly half of all MS sufferers. A key instigator of this pain is the pro-inflammatory response in MS.
Apostolopoulos, Vasso, Moalem-Taylor, G, Perera, CJ, Tian, DH   +3 more
core   +2 more sources

MicroRNAs Contribute to Promyelocyte Apoptosis in As2O3-Treated APL Cells

Cellular Physiology and Biochemistry, 2013
Background: Arsenic trioxide (As2O3), an ancient drug used in traditional Chinese medicine, has substantial anticancer activities, especially in the treatment of patients suffering from acute promyelocytic leukemia (APL); however the underlying ...
Haihai Liang, Xuelian Li, Lu Wang, Shaonan Yu, Zhidan Xu, Yunyan Gu, Zhenwei Pan, Tianyu Li, Meiyu Hu, Hairong Cui, Xue Liu, Ying Zhang, Chaoqian Xu, R. Guo, Yanjie Lu, Baofeng Yang, H. Shan   +16 more
semanticscholar   +1 more source

Disease Progression in Multiple System Atrophy: The ASPIRE Multi‐Modal Biomarker Study

Annals of Neurology, EarlyView.
Objective The objective of this study was to characterize changes in candidate biomarkers in early multiple system atrophy (MSA) and identify baseline predictors of faster progression. Methods This 1‐year, multicenter, prospective study assessed clinical, neuroimaging (3T‐magnetic resonance imaging [MRI], dopamine transporter single‐photon emission ...
Margherita Fabbri, Natalia del Campo, Wassilios G. Meissner, Vanessa Rousseau, Agnès Sommet, Pierre Payoux, Pierre Gantet, Amel Drif, Hélène Catalá, Claire Thalamas, Christine Tranchant, Franck Durif, Ana Marques, Alexandre Eusebio, Luc Defebvre, Jean‐Christophe Corvol, Stéphane Thobois, Anthime Flaus, Anne‐Gaelle Corbille, Solène Frismand, Beverley Patterson, Alexandra Foubert‐Samier, Anne Pavy‐Le Traon, Germain Arribarat, Patrice Péran, Olivier Rascol, for the ASPIRE Study Group   +26 more
wiley   +1 more source

Adefovir dipivoxil inhibits APL progression through degradation of the oncoprotein PML-RARA

Experimental Hematology & Oncology, 2022
Acute promyelocytic leukemia (APL) is highly aggressive and is frequently associated with disseminated intravascular coagulation and high early death rates. Although all-trans retinoic acid (RA) induces complete remission in a high proportion of patients
Xubo Gong, Piaoping Kong, Teng Yu, Xibin Xiao, Lin Wang, Yiwen Sang, Xiang Li, Bin Zhang, Zhihua Tao, Weiwei Liu   +9 more
doaj   +1 more source

Government response to consultation on choice and flexibility: Additional Paternity Leave and Pay [PDF]

, 2010
Sets out the Government's response to a public consultation on the legal and technical espects of the Additional Paternity Leave and Pay (APL&P ...

core  

Prognostic Value of Lupus Anticoagulant and Anti–β2 Glycoprotein I Antibody in Adverse Pregnancy Outcomes

Arthritis &Rheumatology, EarlyView.
Objective International criteria for antiphospholipid syndrome (APS) include lupus anticoagulant (LA), anticardiolipin (aCL) IgG and IgM, and anti–β2‐glycoprotein I (β2GPI) IgG and IgM. However, evidence supporting their prognostic value or treatment efficacy in improving live birth rates is limited.
Megumi Nonobe, Takahiro Otani, Hiroyuki Yoshihara, Shinobu Goto, Tamao Kitaori, Naomi Nishikawa, Yuichiro Fujieda, Tatsuya Atsumi, Mayumi Sugiura‐Ogasawara   +8 more
wiley   +1 more source

Development and Validation of a LC/MS/MS Method for the Determination of Duloxetine in Human Plasma and Its Application to Pharmacokinetic Study

E-Journal of Chemistry, 2012
A selective, high sensitive and high throughput liquid chromatography-tandem mass spectrometry (LC-ESI-MS/MS) method has been developed and validated for the chromatographic separation and quantitation of duloxetine in human EDTA plasma using fluoxetine (
D. Chandrapal Reddy, A. T. Bapuji, V. Surayanarayana Rao, V. Himabindu, D. Rama Raju, Syed Syedba, H. L. V. Ravikiran   +6 more
doaj   +1 more source