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Outcome of aplastic anaemia in children. A study by the severe aplastic anaemia and paediatric disease working parties of the European group blood and bone marrow transplant [PDF]

British Journal of Haematology, 2015
This study analysed the outcome of 563 Aplastic Anaemia (AA) children aged 0-12 years reported to the Severe Aplastic Anaemia Working Party database of the European Society for Blood and Marrow Transplantation, according to treatment received.
Marta Pillon, Antonio M Risitano
exaly   +3 more sources

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Aplastic anaemia: Current concepts in diagnosis and management

Journal of Paediatrics and Child Health, 2020
Aplastic anaemia is a rare, previously fatal condition with a significantly improved survival rate owing to advances in understanding of the pathophysiology and improved treatment strategies including haematopoietic stem cell transplantation.
Eliska Furlong
exaly   +2 more sources

Impact of Human Leucocyte Antigen epitope matched platelet transfusions in alloimmunised aplastic anaemia patients

Transfusion Medicine, 2020
To explore the impact of Human Leucocyte Antigen (HLA)‐A and B epitope‐matched platelets on the outcome of platelet transfusions in alloimmunised patients with aplastic anaemia (AA). The relevance of HLA‐C epitope mismatches was also investigated.
D. Kallon, Cristina V. Navarrete, Deborah A. Sage, S. Stanworth, G. Mufti, Judith C. W. Marsh, C. Brown   +6 more
semanticscholar   +1 more source

Romiplostim in patients with refractory aplastic anaemia previously treated with immunosuppressive therapy: a dose-finding and long-term treatment phase 2 trial.

The Lancet Haematology, 2019
BACKGROUND Aplastic anaemia is a rare, life-threatening condition, characterised by pancytopenia with hypocellular bone marrow. Haematopoietic stem cells and most progenitor cells express thrombopoietin receptor (c-MPL). Romiplostim is a peptibody with c-
J. W. Lee, Sung-Eun Lee, C. Jung, S. Park, Hiroyuki Keta, Soo Kyeong Park, Jin-A Kim, I. Oh, J. Jang   +8 more
semanticscholar   +1 more source

Activity and safety of eltrombopag in combination with cyclosporin A as first‑line treatment of adults with severe aplastic anaemia (SOAR): a phase 2, single-arm study.

The Lancet Haematology
BACKGROUND Antithymocyte globulin (ATG)-based immunosuppression is standard in front-line treatment for people with severe aplastic anaemia without a histocompatible donor or who are 40 years or older. However, ATG requires in-hospital administration, is
P. Scheinberg, C. Finelli, E. Montaño-Figueroa, Carlos Vallejo, L. Norasetthada, Rodrigo T. Calado, Mehmet Turgut, R. Peffault de Latour, U. Kriemler-Krahn, J. Haenig, Joan Clark, Jun-Ho Jang   +11 more
semanticscholar   +1 more source

Integrated analysis of global gene and microRNA expression profiling associated with aplastic anaemia.

Life Science, 2019
AIMS Aplastic anaemia is a rare disorder characterized by peripheral pancytopenia and hypocellular bone marrow. Recent advancement of miRNA technologies, new promising therapy using small molecule inhibitors was suggested as efficient treatment option ...
Sarmistha Adhikari, Paramita Mandal
semanticscholar   +1 more source

Adverse transfusion reactions in patients with aplastic anaemia or myelodysplastic syndromes

Vox Sanguinis, 2019
Patients with aplastic anaemia or myelodysplastic syndromes frequently receive transfusions in an attempt to correct anaemia and/or thrombocytopenia, putting them at risk of adverse transfusion reactions.
P. Moncharmont, Elodie Quittançon, G. Barday, A. Benamara   +3 more
semanticscholar   +1 more source

Aplastic anaemia in pregnancy – a single centre, North American series

British Journal of Haematology, 2018
Aplastic anaemia (AA) is infrequently observed in pregnancy. We describe 19 pregnancies in 9 women at a tertiary care centre over a period of 30 years.
K. McGowan, A. Malinowski, A. Schuh, W. Whittle, Nadine Shehata   +4 more
semanticscholar   +1 more source

Unmanipulated haploidentical transplantation conditioning with busulfan, cyclophosphamide and anti-thymoglobulin for adult severe aplastic anaemia

Bone Marrow Transplantation, 2018
L.-P. Xu, Z.-L. Xu, F.-R. Wang, X. Mo, T. Han, W. Han, Y.-H. Chen, Y.-Y. Zhang, J.-Z. Wang, Y. Wang, Chen-Hua Yan, Y.-Q. Sun, F. Tang, X.-H. Zhang, X.-J. Huang   +14 more
semanticscholar   +1 more source