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Lancet, The, 2005
Aplastic anaemia is a rare haemopoietic stem-cell disorder that results in pancytopenia and hypocellular bone marrow. Although most cases are acquired, there are unusual inherited forms. The pathophysiology of acquired aplastic anaemia is immune mediated in most cases; autoreactive lymphocytes mediate the destruction of haemopoietic stem cells ...
Robert Brodsky
exaly +3 more sources
Aplastic anaemia is a rare haemopoietic stem-cell disorder that results in pancytopenia and hypocellular bone marrow. Although most cases are acquired, there are unusual inherited forms. The pathophysiology of acquired aplastic anaemia is immune mediated in most cases; autoreactive lymphocytes mediate the destruction of haemopoietic stem cells ...
Robert Brodsky
exaly +3 more sources
Acta Medica Scandinavica, 1972
Abstract Eighty patients with aplastic anaemia have been found among 1.2 mill. inhabitants in Sweden during the 5‐year period 1964–68, corresponding to an incidence of 13/1 mill. and year. Only 13 patients (16%) were alive 3–7 years after the initial symptoms, most patients dying after a comparatively short time (<2 y.).
L E, Böttiger, B, Westerholm
+5 more sources
Abstract Eighty patients with aplastic anaemia have been found among 1.2 mill. inhabitants in Sweden during the 5‐year period 1964–68, corresponding to an incidence of 13/1 mill. and year. Only 13 patients (16%) were alive 3–7 years after the initial symptoms, most patients dying after a comparatively short time (<2 y.).
L E, Böttiger, B, Westerholm
+5 more sources
Blood Reviews, 2000
Acquired, idiosyncratic aplastic anaemia (AA) is a rare but potentially fatal haematological disorder. Severe AA constitutes an acute medical emergency, and supportive therapy is needed to prevent overwhelming sepsis or a life threatening haemorrhage. Specific therapy for the disease includes the choice between allogeneic stem cell transplantation (SCT)
S B, Killick, J C, Marsh
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Acquired, idiosyncratic aplastic anaemia (AA) is a rare but potentially fatal haematological disorder. Severe AA constitutes an acute medical emergency, and supportive therapy is needed to prevent overwhelming sepsis or a life threatening haemorrhage. Specific therapy for the disease includes the choice between allogeneic stem cell transplantation (SCT)
S B, Killick, J C, Marsh
openaire +2 more sources
Irish Journal of Medical Science, 1964
1. In one family four out of eight children have died with pigmentation, pancytopenia and progressive bone marrow failure. The disease was an incomplete form of Fanconi’s aplastic anaemia. 2. The family have been under observation for eight years.
M G, NELSON, J T, LEWIS, J H, ROBERTSON
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1. In one family four out of eight children have died with pigmentation, pancytopenia and progressive bone marrow failure. The disease was an incomplete form of Fanconi’s aplastic anaemia. 2. The family have been under observation for eight years.
M G, NELSON, J T, LEWIS, J H, ROBERTSON
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Aplastic Anaemia and Polyneuropathy
Acta Haematologica, 2009We report a previously undocumented association between aplastic anaemia and acute idiopathic polyneuropathy and speculate that it was due to an antibody cross-reacting with haematopoietic stem cells and myelin.
P N, Foster, P R, Kelsey
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Hypoimmunoglobulinaemia and Aplastic Anaemia
Scandinavian Journal of Haematology, 1977Serum immunoglobulin levels were estimated in 19 patients with aplastic anaemia. Although the mean levels for IgG, IgA and IgM for the group as a whole were within the normal range, 8 individual cases showed low levels of one or more immunoglobulin class, suggesting a disturbance in immunoglobulin production.
M A, Mir, C G, Geary, I W, Delamore
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Pathophysiology of aplastic anaemia
Blood Reviews, 1990No single pathophysiological phenomenon--neither the intrinsic defect of haemopoiesis nor any of the described immune effects--explains aplastic anaemia. Since the intrinsic defect is compatible with near normal haemopoietic function, as seen in autologous bone marrow reconstitution, it cannot be the cause of severe pancytopenia.
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The Hematology Journal, 2003
A number of inherited (constitutional/genetic) disorders are characterized by bone marrow (BM) failure/aplastic anaemia (AA) usually in association with one or more somatic abnormality. Occasionally, these patients may present with AA alone and be labelled to have idiopathic AA.
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A number of inherited (constitutional/genetic) disorders are characterized by bone marrow (BM) failure/aplastic anaemia (AA) usually in association with one or more somatic abnormality. Occasionally, these patients may present with AA alone and be labelled to have idiopathic AA.
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APLASTIC ANAEMIA IN THE ORIENT
British Journal of Haematology, 1986N S, Young +3 more
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