Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley +1 more source
Why antimicrobial resistance messaging fails: qualitative insights interpreted through the elaboration likelihood model. [PDF]
Krockow EM +4 more
europepmc +1 more source
Hope, But Not for Us: Ecological Science Fiction and the End of the World in Margaret Atwood\u27s \u3cem\u3eOryx and Crake\u3c/em\u3e and \u3cem\u3eThe Year of the Flood\u3c/em\u3e [PDF]
Canavan, Gerry
core +1 more source
Autophagosome marker, LC3, is released extracellularly via several distinct pathways
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito +3 more
wiley +1 more source
The lambs of sheepfoot lane: Oldham Athletic AFC 1960-2023; football, politics and identity. [PDF]
O'Brien J.
europepmc +1 more source
Many Lamps Are Lightened From the One : Paradigms of the Transformational Vision in Macarian Homilies [PDF]
Orlov, Andrei
core +1 more source
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman +4 more
wiley +1 more source
Thinking about returning home from a protected haematology unit: confronting healthcare providers' representations and patients' experiences in a qualitative study. [PDF]
Letrecher S, Chemrouk Y, Sani L.
europepmc +1 more source
TMC4 localizes to multiple taste cell types in the mouse taste papillae
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata +6 more
wiley +1 more source

