Polyphenol diet and exercise as neuroprotective factors in a Drosophila model of Alzheimer's disease
Animal Models and Experimental Medicine, EarlyView.Moderate exercise and low‐dose ellagic acid supplementation improved motor performance, learning, and longevity in a transgenic Drosophila model of Alzheimer's disease. Both interventions showed hormetic effects—that is, beneficial at low levels, but detrimental at higher intensities or doses.
Michelle Morgan +2 more
wiley +1 more source
Protective associations of HDL with blood-brain barrier injury in multiple sclerosis patients
Journal of Lipid Research, 2015 The purpose of this work was to investigate the associations of serum cholesterol and apolipoproteins with measures of blood-brain barrier (BBB) permeability and CNS inflammation following the first clinical demyelinating event.
Kelly Fellows +12 more
doaj +1 more source
LCAT cholesterol esterification is associated with the increase of ApoE/ApoA-I ratio during atherosclerosis progression in rabbit [PDF]
, 2011 Apolipoprotein A-I and Apolipoprotein E promote different steps of reverse cholesterol transport, including lecithin-cholesterol acyltransferase stimulation.
A. Carlucci +6 more
core +1 more source
Generating golden Syrian hamsters with conditional alleles via zygote microinjection of CRISPR/Cas9
Animal Models and Experimental Medicine, EarlyView.We established the first conditional knockout (cKO) model in the golden Syrian hamster by CRISPR/Cas9‐mediated genome editing. Cas9 protein, two sgRNAs, and a donor plasmid carrying loxP‐flanked exon 2 of the ApoF gene were microinjected into one‐cell embryos. The floxed allele was efficiently generated (up to 27%) and transmitted through the germline.
Wei Chen +16 more
wiley +1 more source
A thumbwheel mechanism for APOA1 activation of LCAT activity in HDL[S]
Journal of Lipid Research, 2018 APOA1 is the most abundant protein in HDL. It modulates interactions that affect HDL';s cardioprotective functions, in part via its activation of the enzyme, LCAT.
Allison L. Cooke +12 more
doaj +1 more source
Animal Models and Experimental Medicine, EarlyView.An 18‐month HFD successfully established a translational Macaca fascicularis model replicating key metabolic disorders (MASH, diabetes, cardiac hypertrophy). MASH was determined by liver biopsy histology, the presence steatosis, inflammatory infiltration, hepatocytic ballooning, and fibrosis were considered as MASH; diabetes was diagnosed according to ...
Hongyi Chen +12 more
wiley +1 more source
Impact of individual acute phase serum amyloid A isoforms on HDL metabolism in mice[S]
Journal of Lipid Research, 2016 The acute phase (AP) reactant serum amyloid A (SAA), an HDL apolipoprotein, exhibits pro-inflammatory activities, but its physiological function(s) are poorly understood.
Myung-Hee Kim +7 more
doaj +1 more source
Establishment of a mouse model of TMAO‐induced cardiac injury and application of MICT intervention
Animal Models and Experimental Medicine, EarlyView.This study aims to explore the establishment of an animal model of cardiac injury induced by trimethylamine‐N‐oxide (TMAO), a metabolite secreted by gut microorganisms, and to investigate its application in moderate‐intensity continuous training (MICT) intervention.
Zhongping Xie +4 more
wiley +1 more source
Apolipoprotein E ɛ4 Allele Increases Risk for Psychotic Symptoms in Alzheimer's Disease [PDF]
, 2006 Kristina Zdanys +9 more
openalex +1 more source
Journal of Lipid Research, 1999 High density lipoprotein (HDL) phospholipids and apolipoproteins remove cellular lipids by two distinct mechanisms, but their relative contribution to reverse cholesterol transport is unknown.
John F. Oram +4 more
doaj +1 more source