Results 121 to 130 of about 56,097 (295)

Nucleotide sequence and structure of the human apolipoprotein E gene. [PDF]

, 1985
Young‐Ki Paik, David J. Chang, Catherine A. Reardon, Gareth E. Davies, Robert W. Mahley, John M. Taylor   +5 more
openalex   +1 more source

Apolipoprotein [PDF]

, 2018
K. J. Lackner, D. Peetz
openaire   +1 more source

Amyloid‐Related Imaging Abnormality (ARIA) Beyond the APOE‐ε4 Allele

Chronic Diseases and Translational Medicine, EarlyView.
Mechanism of action of monoclonal antibodies targeting Aβ in the treatment of AD. (A) Targets of various mAbs. (B) Mechanism of monoclonal antibody‐mediated clearance of Aβ. mAbs facilitate the clearance of Aβ by enhancing microglial‐mediated phagocytosis through the upregulation of TREM2 expression.
Valentinus Besin, Farizky Martriano Humardani, Fenny Lanawati Yudiarto, Paulus Anam Ong, Sulistyo Emantoko Dwi Putra, Ratih Asmana Ningrum   +5 more
wiley   +1 more source

HDL‐C/LDL‐C Ratio and All‐Cause Mortality in Populations at High CVD Risk: A Prospective Observational Cohort Study

Chronic Diseases and Translational Medicine, EarlyView.
ABSTRACT Background The ratio of high‐density lipoprotein cholesterol (HDL‐C) to low‐density lipoprotein cholesterol (LDL‐C) predicts cardiovascular disease (CVD) endpoints, yet its prognostic validity in high‐risk populations and for type 2 diabetes mellitus (T2DM)‐related adverse events remains unestablished. Methods This study included 32,609 people
Biting Lin, Yunzhi Ling, Gengyu Zhou, Ziqing Ruan, Fan Chen, Simiao Chen, Tingting Weng, Yuanfan Zhu, Jingyi Lin, Ling Yu, Kaiyang Lin   +10 more
wiley   +1 more source

Omega-3 fatty acids, lipids, and apoE lipidation in Alzheimer's disease: a rationale for multi-nutrient dementia prevention

Journal of Lipid Research, 2017
In the last decade, it has become obvious that Alzheimer's disease (AD) is closely linked to changes in lipids or lipid metabolism. One of the main pathological hallmarks of AD is amyloid-β (Aβ) deposition.
Marcus O.W. Grimm, Daniel M. Michaelson, Tobias Hartmann   +2 more
doaj  

Identification of circulating apolipoproteins synthesized by rat small intestine in vivo.

, 1978
A.L. Wu, H.G. Windmueller
openalex   +1 more source

Determination of the molecular mass of apolipoprotein B-100 A chemical approach [PDF]

, 1986
Chao Yang, F.S. Lee, Lawrence Chan, Doris A. Sparrow, James T. Sparrow, Antonio M. Gotto   +5 more
openalex   +1 more source

Variation in Neurodegeneration‐Linked Brain Regions in Young Adult APOE E4 Carriers With Spina Bifida

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Objective Possible pleiotropic effects of apolipoprotein E4 (APOE E4) in individuals with congenital brain malformations are relatively unknown. Our goal was to determine if neurodegeneration‐linked brain region volumes differ significantly between E4 carriers and noncarriers in young adults with spina bifida (SB). Methods Eleven individuals ( 
Joan M. Jasien, Jacques A. Stout, Mohamad A. Mikati, Robert J. Anderson, Brittany G. Nave, Herbert E. Fuchs, Brian Smith, Alexandra Badea, Jeffrey N. Browndyke   +8 more
wiley   +1 more source

Effect of antiretroviral therapy on allele-associated Lp(a) level in women with HIV in the Women's Interagency HIV Study

Journal of Lipid Research, 2018
We previously demonstrated an association between lipoprotein (a) [Lp(a)] levels and atherosclerosis in human immunodeficiency virus (HIV)-seropositive women.
Byambaa Enkhmaa, Erdembileg Anuurad, Wei Zhang, Chin-Shang Li, Robert Kaplan, Jason Lazar, Dan Merenstein, Roksana Karim, Brad Aouizerat, Mardge Cohen, Kenneth Butler, Savita Pahwa, Igho Ofotokun, Adaora A. Adimora, Elizabeth Golub, Lars Berglund   +15 more
doaj  

Model‐Informed Drug Development Applications and Opportunities in mRNA‐LNP Therapeutics

Clinical Pharmacology &Therapeutics, EarlyView.
The utilization of lipid nanoparticles (LNP) for encapsulating mRNA has revolutionized the field of therapeutics, enabling the rapid development of COVID‐19 vaccines and cancer vaccines. However, the clinical development of mRNA‐LNP therapeutics faces numerous challenges due to their complex mechanisms of action and limited clinical experience.
Jiawei Zhou, Rohit Rao, Monica E. Shapiro, Nessy Tania, Cody Herron, Cynthia J. Musante, Jim H. Hughes   +6 more
wiley   +1 more source