Results 131 to 140 of about 78,568 (336)

The complexity of dementia development and its comorbidities: The collaborative cross‐mouse population for multivarious tasks approach

Animal Models and Experimental Medicine, EarlyView.
The increasing prevalence of dementia and related neurodegenerative diseases—including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis—poses a growing public health challenge. These conditions have traditionally been studied as isolated central nervous system disorders, but emerging evidence points to ...
Osayd Zohud, Iqbal M. Lone, Kareem Midlej, Fuad A. Iraqi   +3 more
wiley   +1 more source

Figure SF2 from Apolipoprotein E Promotes Immune Suppression in Pancreatic Cancer through NF-κB–Mediated Production of CXCL1 [PDF]

, 2023
Samantha B. Kemp, Eileen S. Carpenter, Nina G. Steele, Katelyn L. Donahue, Zeribe C. Nwosu, Amanda Pacheco, Ashley Velez-Delgado, Rosa E. Menjivar, Fátima Lima, Stephanie The, Carlos E. Espinoza, Kristee Brown, Daniel Long, Costas A. Lyssiotis, Arvind Rao, Yaqing Zhang, Marina Pasca di Magliano, Howard C. Crawford   +17 more
openalex   +1 more source

The ratio of low-density lipoprotein cholesterol to apolipoprotein-B as a marker of low-density lipoprotein particle size

Атеросклероз, 2018
The aim of this study was to determine the informative value and clinical significance of the ratio of low-density lipoprotein cholesterol to apolipoprotein-B (LDL-C/apoB) in the overall evaluation of blood lipid profile atherogenicity.
A. M. Kaneva, N. N. Potolitsyna, E. R. Bojko   +2 more
doaj   +1 more source

Quantitative proteomics identifies clusterin as a novel biomarker for atherosclerosis

Animal Models and Experimental Medicine, EarlyView.
This schematic illustrates the proposed mechanism. In advanced atherosclerotic lesions, upregulated CLU on the cell surface activates low‐density lipoprotein (LDL) receptor‐related protein 1 (LRP1). This interaction triggers the phosphorylation and activation of AKT.
Dengfeng Ding, Yingjie Zhang, Li Zhang, Xinou Zheng, Miaomiao Niu, Yunxiao Jia, Xuezhuang Li, Hua Chen, Chao Guo, Tao Jiang, Yuqiong Zhao   +10 more
wiley   +1 more source

Apolipoprotein A5 , a Newly Identified Gene That Affects Plasma Triglyceride Levels in Humans and Mice [PDF]

, 2003
L Pennacchio, Edward M. Rubin
openalex   +1 more source

Omega-3 fatty acids, lipids, and apoE lipidation in Alzheimer's disease: a rationale for multi-nutrient dementia prevention

Journal of Lipid Research, 2017
In the last decade, it has become obvious that Alzheimer's disease (AD) is closely linked to changes in lipids or lipid metabolism. One of the main pathological hallmarks of AD is amyloid-β (Aβ) deposition.
Marcus O.W. Grimm, Daniel M. Michaelson, Tobias Hartmann   +2 more
doaj   +1 more source

Apolipoprotein B48 RNA Editing in Chimeric Apolipoprotein EB mRNA

Journal of Biological Chemistry, 1989
Apolipoprotein (apo) B occurs in two forms, apoB100 (512 kDa) and apoB48 (240 kDa); both are derived from the same gene. A novel mechanism involving editing of the apoB mRNA causes the formation of apoB48; the first base of codon 2153 is changed from cytosine to uracil, converting a glutamine codon to a premature stop codon.
K, Boström, S J, Lauer, K S, Poksay, Z, Garcia, J M, Taylor, T L, Innerarity   +5 more
openaire   +2 more sources

Persisting Transglutaminase 6 Antibodies in Neurological Gluten‐Related Disorders

Annals of Neurology, EarlyView.
Objective Gluten‐related autoimmunity can cause neurological disease, although the best way to diagnose and monitor such patients is unclear. Serological testing for antibodies against transglutaminase 6 (TG6) has been proposed; however, this is not widely available in clinical practice.
Iain D. Croall, Marios Hadjivassiliou, David S. Sanders, Kevin Teh, Alberto M. Biancardi, Nick Trott, Nigel Hoggard   +6 more
wiley   +1 more source

Lipid Binding-induced Conformational Change in Human Apolipoprotein E [PDF]

, 2001
Hiroyuki Saito, Padmaja Dhanasekaran, Faye Baldwin, Karl H. Weisgraber, Sissel Lund‐Katz, Michael C. Phillips   +5 more
openalex   +1 more source

Properties of triglyceride-rich and cholesterol-rich lipoproteins in the remnant-like particle fraction of human blood plasma

Journal of Lipid Research, 2002
An immunoassay procedure that quantifies remnant-like particle (RLP) cholesterol in human blood plasma has shown considerable promise as a clinically applicable risk marker for atherosclerotic disease.
Elisa Campos, Leila Kotite, Patricia Blanche, Yasushi Mitsugi, Philip H. Frost, Umesh Masharani, Ronald M. Krauss, Richard J. Havel   +7 more
doaj   +1 more source