Copper in cancer: friend or foe? Metabolism, dysregulation, and therapeutic opportunities
Cancer Communications, EarlyView.Abstract Copper, one of the essential nutrients for the human body, acts as an electron relay in multiple pathways due to its redox properties. Both deficiencies and excesses of copper lead to cellular fragility. Therefore, it can manifest pro‐ and anti‐cancer properties in tumors. Therefore, it is crucial to clarify the copper activity within the cell.
Dan Shan +13 more
wiley +1 more source
One-step screening method for the polymorphism of apolipoproteins A-I, A-II, and A-IV
Journal of Lipid Research, 1982 Apolipoprotein A-I exhibits a polymorphism that can be easily investigated in native serum by a simple method involving incubation of serum in the presence of decylsulfate and beta-mercaptoethanol and subsequent isoelectric focusing.
H J Menzel, R G Kladetzky, G Assmann
doaj
Modeling Interconnected Modules in Multivariate Outcomes: Evaluating the Impact of Alcohol Intake on Plasma Metabolomics [PDF]
arXivAlcohol consumption has been shown to influence cardiovascular mechanisms in humans, leading to observable alterations in the plasma metabolomic profile. Regression models are commonly employed to investigate these effects, treating metabolomics features as the outcomes and alcohol intake as the exposure. Given the latent dependence structure among the
arxiv
Serotonergic modulators in Alzheimer's disease: a hope in the hopeless condition
Chemistry &Biodiversity, Accepted Article.Alzheimer disease (AD) is the main cause of dementia worldwide. AD is a progressive brain neurodegenerative disease due to genetic and environmental factors that induce a progressive accumulation of intracellular hyperphosphorylated tau protein and extracellular amyloid protein (Aβ).
Ali I. Al-Gareeb +5 more
wiley +1 more source
Journal of Lipid Research, 1997 The class B type I scavenger receptor, SR-BI, binds HDL, mediates selective uptake of HDL cholesteryl esters by cultured cells, and its expression is coordinately regulated with steroidogenesis in several endocrine tissues (adrenal, ovary, testes). SR-BI
S Xu +5 more
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Serum total lipids, lipoprotein cholesterol, and apolipoprotein A in acute viral hepatitis and chronic liver disease. [PDF]
, 1978 Carlo Vergani +4 more
openalex +1 more source
Lipid Metabolism and Immune Function: Chemical Tools for Insights into T‐Cell Biology
ChemBioChem, EarlyView.This review explores how lipids regulate immune responses, particularly in T‐cell function. Advances in metabolomics and proteomics provide insights into lipid‐mediated immunity. Fluorescent lipids enable single‐cell analysis of lipid uptake and metabolism.
Luuk Reinalda +2 more
wiley +1 more source
Surface pressure-dependent conformation change of apolipoprotein-derived amphipathic α-helices
Journal of Lipid Research, 2013 Amphipathic α-helices (AαH) are the primary structural motif of exchangeable apolipoproteins. AαHs in exchangeable apolipoproteins adsorb, remodel, and desorb at the surface of plasma lipoproteins in response to changes in their size or composition.
Matthew A. Mitsche, Donald M. Small
doaj
Charge-shift electrophoresis of apolipoproteins from normal humans and patients with tangier disease [PDF]
, 1979 Gerd Utermann, Ulrike Beisiegel
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ChemBioChem, EarlyView.Regulated intramembrane proteolysis is crucial for functional proteome in all kingdoms of life. The task of cleaving transmembrane proteins within the unique environment of the lipid bilayer presents biochemical challenges that has been solved by integral membrane proteases (IMPRs).
Hannah Fremlén, Björn M. Burmann
wiley +1 more source