Results 151 to 160 of about 55,604 (311)

GREM1 deficiency induced bone marrow adipose niche promotes B‐cell acute lymphoblastic leukemia disease progression

open access: yesInternational Journal of Cancer, EarlyView.
What's New? Too often, children treated for B‐cell acute lymphocytic leukemia (B‐ALL) experience relapse. Here, the authors investigate the role of dyslipidemia in leukemia progression. Higher adipogenicity in bone marrow mesenchymal stem cells, and increased triglyceride accumulation, are associated with higher risk of death.
Lili Song   +10 more
wiley   +1 more source

Effects of antisense-mediated inhibition of 11β-hydroxysteroid dehydrogenase type 1 on hepatic lipid metabolism[S]

open access: yesJournal of Lipid Research, 2011
11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) converts inactive 11-keto derivatives to active glucocorticoids within tissues and may play a role in the metabolic syndrome (MS).
Guoping Li   +4 more
doaj  

Sex‐specific associations of Roseburia with uric acid metabolism and hyperuricemia risk in females

open access: yesiMetaOmics, EarlyView.
Researchers recruited 623 participants, including 270 females, and used 16S rDNA sequencing to investigate gender differences in hyperuricemia. In healthy females, Roseburia was enriched, positively correlating with estrogen and negatively with uric acid, suggesting it is a potential biomarker affecting uric acid levels in females.
Zhihan Yang   +8 more
wiley   +1 more source

Acidification of the intimal fluid: the perfect storm for atherogenesis

open access: yesJournal of Lipid Research, 2015
Atherosclerotic lesions are often hypoxic and exhibit elevated lactate concentrations and local acidification of the extracellular fluids. The acidification may be a consequence of the abundant accumulation of lipid-scavenging macrophages in the lesions.
Katariina Öörni   +6 more
doaj  

Structure, evolution, and polymorphisms of the human apolipoprotein A4 gene (APOA4). [PDF]

open access: green, 1986
Sotirios K. Karathanasis   +3 more
openalex   +1 more source

Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease

open access: yesiMetaOmics, EarlyView.
This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu   +8 more
wiley   +1 more source

Properties of triglyceride-rich and cholesterol-rich lipoproteins in the remnant-like particle fraction of human blood plasma

open access: yesJournal of Lipid Research, 2002
An immunoassay procedure that quantifies remnant-like particle (RLP) cholesterol in human blood plasma has shown considerable promise as a clinically applicable risk marker for atherosclerotic disease.
Elisa Campos   +7 more
doaj  

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