Results 11 to 20 of about 55,604 (311)
Gain and loss events in the evolution of the apolipoprotein family in vertebrata
BMC Evolutionary Biology, 2019 Background Various apolipoproteins widely distributed among vertebrata play key roles in lipid metabolism and have a direct correlation with human diseases as diagnostic markers.
Jia-Qian Liu +5 more
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An MRM-Based Multiplexed Quantification Assay for Human Adipokines and Apolipoproteins
Molecules, 2020 Adipokines and apolipoproteins are key regulators and potential biomarkers in obesity and associated diseases and their quantitative assessment is crucial for functional analyses to understand disease mechanisms.
Laura Krieg +9 more
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Vision, 2022 Serum apolipoproteins have been reported as a more significant marker for diabetic retinopathy (DR) compared with serum cholesterols. This article aims to review the associations between serum cholesterols and apolipoproteins, and the presence and ...
Soefiandi Soedarman +3 more
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Nanomaterials, 2020 Apolipoproteins are critical structural and functional components of lipoproteins, which are large supramolecular assemblies composed predominantly of lipids and proteins, and other biomolecules such as nucleic acids.
Skylar T. Chuang +2 more
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Molecules, 2021 Oxidative modifications of HDLs and LDLs by myeloperoxidase (MPO) are regularly mentioned in the context of atherosclerosis. The enzyme adsorbs on protein moieties and locally produces oxidizing agents to modify specific residues on apolipoproteins A-1 ...
Catherine Coremans +5 more
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Molecular Dynamics Simulation of Apolipoprotein E3 Lipid Nanodiscs [PDF]
arXiv, 2023 Nanodiscs are binary discoidal complexes of a phospholipid bilayer circumscribed by belt-like helical scaffold proteins. Using coarse-grained and all-atom molecular dynamics simulations, we explore the stability, size, and structure of nanodiscs formed between the N-terminal domain of apolipoprotein E3 (apoE3-NT) and variable number of 1,2-dimyristoyl ...
arxiv
Degradation of human apolipoprotein B‐100 by apolipoprotein(a)
FEBS Letters, 1993 Human plasma low density lipoproteine (LDL) contain a very high molecular weight protein termed apoB‐100 (M r = 550,000). In many samples of LDL, minor components designated as apoB‐74 (M r = 407,000) and apoB‐26 (M r = 145,000) are present. It has been shown that they can arise as a result of proteolytic degradation of apoB‐100.
V.V. Tertov, T.M. Chulkova
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Apolipoprotein mimetics in cancer
Seminars in Cancer Biology, 2021 Peptides have many advantages over traditional therapeutics, including small molecules and other biologics, because of their low toxicity and immunogenicity, while still exhibiting efficacy. This review discusses the benefits and mechanism of action of apolipoprotein mimetic peptides in tumor biology and their potential utility in treating various ...
Delk, Samuel C +4 more
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Endothelial Cell-specific Loss of Breast Cancer Susceptibility Gene 2 Exacerbates Atherosclerosis [PDF]
arXiv, 2023 The BReast CAncer type 2 susceptibility protein (BRCA2) responds to DNA damage by participating in homology-directed repair. BRCA2 deficiency culminates in defective DNA damage repair (DDR) that when prolonged leads to the accumulation of DNA damage causing cancer or apoptosis.
arxiv
Journal of Biological Chemistry, 1990 In this report, we have identified two apolipoproteins (apo), apoD and apoA-IV, that, together with the previously identified apoA-I and apoE, accumulate in the regenerating peripheral nerve. These four apolipoproteins were identified in regenerating rat sciatic nerves by their molecular weights, their isoelectric points, and their recognition by ...
L J Anderson +2 more
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