Results 41 to 50 of about 45,443 (285)

The cardiovascular phenotype of adult patients with phenylketonuria [PDF]

, 2019
BACKGROUND: Patients with Phenylketonuria (PKU) are exposed to multiple cardiovascular risk factors, but the clinical significance of these abnormalities is yet unknown.
Azabdaftari, Aline, Giet, Markus van der, Hennermann, Julia B., Plöckinger, Ursula, Querfeld, Uwe, Schuchardt, Mirjam   +5 more
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Apolipoproteins and Alzheimer's pathophysiology

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2018
Introduction Apolipoproteins of demonstrated importance to brain cholesterol and ß‐amyloid metabolism may serve as novel risk markers for Alzheimer's pathology.
Manja Koch, Steven T. DeKosky, Annette L. Fitzpatrick, Jeremy D. Furtado, Oscar L. Lopez, Lewis H. Kuller, Rachel H. Mackey, Timothy M. Hughes, Kenneth J. Mukamal, Majken K. Jensen   +9 more
doaj   +1 more source

Vergleich dreier Ringversuche zur radioimmunologischen Thyrotropin-Bestimmung nach dem "Münchner Modell" [PDF]

, 1983
Peer ...
Habermann, J., König, A., Marschner, I., Scriba, Peter Christian, van Thiel, D., Wood, W. G.   +5 more
core   +2 more sources

Apolipoprotein A5 and Hypertriglyceridemia [PDF]

Clinical Chemistry, 2005
Hypertriglyceridemia is associated with increased risk of coronary heart disease (CHD) (1)(2)(3)(4)(5), and it is an integral component of the overlapping syndromes of familial combined hyperlipidemia, insulin resistance syndrome, atherogenic lipoprotein profile, and hyperapobetalipoproteinemia (6).
Charlton-Menys, Valentine, Durrington, Paul N.   +1 more
openaire   +2 more sources

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Plasma proteome correlates of lipid and lipoprotein: biomarkers of metabolic diversity and inflammation in children of rural Nepal. [PDF]

, 2019
Proteins involved in lipoprotein metabolism can modulate cardiovascular health. While often measured to assess adult metabolic diseases, little is known about the proteomes of lipoproteins and their relation to metabolic dysregulation and underlying ...
Christian, Parul, Cole, Robert N, Eroglu, Abdulkerim, Groopman, John, Lee, Sun Eun, Schulze, Kerry, Stewart, Christine P, West, Keith P, Wu, Lee S-F, Yager, James D   +9 more
core  

TREM2-dependent effects on microglia in Alzheimer\u27s Disease [PDF]

, 2018
Alzheimer’s disease (AD) is a late-onset dementia characterized by the deposition of amyloid plaques and formation of neurofibrillary tangles (NFTs) which lead to neuronal loss and cognitive deficits.
Colonna, Marco, Ulland, Tyler K, Zhou, Yingyue   +2 more
core   +3 more sources

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Amphipathic α-helices in apolipoproteins are crucial to the formation of infectious hepatitis C virus particles.

PLoS Pathogens, 2014
Apolipoprotein B (ApoB) and ApoE have been shown to participate in the particle formation and the tissue tropism of hepatitis C virus (HCV), but their precise roles remain uncertain.
Takasuke Fukuhara, Masami Wada, Shota Nakamura, Chikako Ono, Mai Shiokawa, Satomi Yamamoto, Takashi Motomura, Toru Okamoto, Daisuke Okuzaki, Masahiro Yamamoto, Izumu Saito, Takaji Wakita, Kazuhiko Koike, Yoshiharu Matsuura   +13 more
doaj   +1 more source