Results 81 to 90 of about 55,323 (311)

Homocysteine Promotes the Pathogenesis of Atherosclerosis through the Circ‐PIAS1‐5/miR‐219a‐2‐3p/TEAD1 Axis

Advanced Science, EarlyView.
A model is schematically represented for the major molecular mechanisms by which homocysteine (Hcy) accelerates the nuclear export of circ‐PIAS1‐5, which regulates atherosclerosis by acting as a competing endogenous RNA for miR‐219a‐2‐3p. Hcy enrichment of circ‐PIAS1‐5 leads to YTHDC1 binding to circ‐PIAS1‐5 and promotes its intracellular localization ...
Shengchao Ma, Fei Ma, Ning Ding, Lin Xie, Anning Yang, Jiangyong Shen, Yun jiao, Kai Wu, YueE Chai, Zhigang Bai, Jiantuan Xiong, Nan Li, Huiping Zhang, Yideng Jiang   +13 more
wiley   +1 more source

Deletion of MyD88 in astrocytes prevents β‐amyloid‐induced neuropathology in mice

Glia, Volume 71, Issue 2, Page 431-449, February 2023., 2023
Main Points MyD88 is upregulated in astrocytes in Alzheimer's disease. Deletion of MyD88 in astrocytes protects against β‐amyloid‐induced synaptic toxicity and cognitive impairment in mice. Abstract As the understanding of immune responses in Alzheimer's disease (AD) is in its early phases, there remains an urgency to identify the cellular and ...
Tee Jong Huat, Tessa Onraet, Judith Camats‐Perna, Estella A. Newcombe, Kim C. Ngo, Ashley N. Sue, Mehdi Mirzaei, Frank M. LaFerla, Rodrigo Medeiros   +8 more
wiley   +1 more source

Sex-Related Differences of the Effect of Lipoproteins and Apolipoproteins on 10-Year Cardiovascular Disease Risk; Insights from the ATTICA Study (2002–2012)

Molecules, 2020
The sex-specific effect of lipid-related biomarkers on 10-year first fatal/non fatal cardiovascular disease (CVD) incidence was evaluated. ATTICA study was conducted during 2001−2012.
Matina Kouvari, Demosthenes B. Panagiotakos, Christina Chrysohoou, Ekavi N. Georgousopoulou, Dimitrios Tousoulis, and Christos Pitsavos   +5 more
doaj   +1 more source

Single‐Cell Analysis Clarifies Pathological Heterogeneity in Tenosynovial Giant Cell Tumor and Identifies Biomarkers for Predicting Disease Recurrence

Advanced Science, EarlyView.
MP3 tumor cells, a specific subpopulation of tumor cells in D‐TGCT, regulated the differentiation of CD34+ Fbs into MMP3+ Fbs and APOE+ Fbs through COL6A3 − (ITGAV + ITGB8) interaction. APOE+ Fbs activated IL‐1B+CCL20+ Mφs through the CXCL12/CXCR4 axis. IL‐1B+CCL20+ Mφs and MMP3+ Fbs participated in the local invasion of D‐TGCT.
Yubin Xie, Chen Chen, Fei Wu, Yiman Peng, Jing Su, Yang Zhao, Hongjie Huang, Zhong Alan Li, Yin Pei, Wencui Li, Yi He, Tianchen Xue, Chenxi Cao, Sui Peng, Xin Zhang, Weidong Song   +15 more
wiley   +1 more source

Optimization of Lipid Nanoparticles with Robust Efficiency for the Delivery of Protein Therapeutics to Augment Cancer Immunotherapy

Advanced Science, EarlyView.
This study develops lipid nanoparticles (LNPs) combining cationic and ionizable lipids for efficient cytosolic protein delivery. Optimized LNPs deliver functional proteins, including antibodies, enzymes, and Cas9, with high serum stability and albumin‐mediated endocytosis.
Lanfang Ren, Zeda Zhao, Yuqing Chao, Panting Yu, Zhoufang Mei, Bing Du, Yiyun Cheng   +6 more
wiley   +1 more source

Distinct cerebral cortical perfusion patterns in idiopathic normal‐pressure hydrocephalus

Human Brain Mapping, Volume 44, Issue 1, Page 269-279, January 2023., 2023
The present study investigates cerebral blood flow (CBF) and cortical thickness using surface‐based analysis of early‐phase 18F‐florbetaben PET and MRI in patients with idiopathic normal‐pressure hydrocephalus (INPH). INPH patients had significantly increased CBF with a concomitant increase in cortical thickness in areas located in the high convexity ...
Kyunghun Kang, Shin Young Jeong, Ki‐Su Park, Myong Hun Hahm, Jaeil Kim, Ho‐Won Lee, Chi‐Hun Kim, Eunkyeong Yun, Jaehwan Han, Uicheul Yoon, Sang‐Woo Lee   +10 more
wiley   +1 more source

Association of apolipoproteins C-I, C-II, C-III and E with coagulation markers and venous thromboembolism risk

Clinical Epidemiology, 2019
Fernanda A Orsi,1,2 Willem M Lijfering,2,3 Arnoud Van der Laarse,4,5 L Renee Ruhaak,4 Frits R Rosendaal,2 Suzanne C Cannegieter,2–3,6 Christa Cobbaert41Department of Clinical Pathology, School of Medical Sciences, University of ...
Orsi FA, Lijfering WM, Van der Laarse A, Ruhaak LR, Rosendaal FR, Cannegieter SC, Cobbaert C   +6 more
doaj  

Effects of a dietary intervention with lacto-ovo-vegetarian and Mediterranean diets on apolipoproteins and inflammatory cytokines: results from the CARDIVEG study

Nutrition & Metabolism
Background Apolipoproteins have been recently proposed as novel markers of cardiovascular disease (CVD) risk. However, evidence regarding effects of diet on apolipoproteins is limited.
Giuditta Pagliai, Marta Tristan Asensi, Monica Dinu, Francesca Cesari, Alessia Bertelli, Anna Maria Gori, Betti Giusti, Rossella Marcucci, Francesco Sofi, Barbara Colombini   +9 more
doaj   +1 more source

Metabolism of apolipoprotein A-IV

Journal of Lipid Research, 1984
The terms “lipoprotein-free’’ and “lipoproteinassociated” are used to denote those studies in which apoA-IV was fractionated by means other than ultracentrifugation. Because of the introduction of artifacts by ultracentrifugation and a reliance of different physical properties for separation by the alternative methods, “lipoprotein- free” and ...
Michael Lefevre, Paul S. Roheim
openaire   +4 more sources

C1q+ Macrophage–Tumor Cell Interaction Promoted Tumorigenesis via GPR17/PI3K/AKT Pathway Induced DNA Hypermethylation in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
In the TME of NPC, C1q secreted by C1q+ TAMs interacted with GPR17 to activate PI3K/AKT signaling through strengthening GPR17 coupling PI3K and increasing calcium levels in tumor cells. The activated PI3K/AKT signaling further induces DNA hypermethylation to promote the malignancy and stemness of tumor cells.
Yunzhi Liu, Cuicui Huang, Min Luo, Wenfu Lu, Baifeng Zhang, Lu Bai, Shuyue Zheng, Yanan Tan, Shanshan Li, Huali Wang, Lanqi Gong, Xinyuan Guan   +11 more
wiley   +1 more source