British Journal of Pharmacology, EarlyView.Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang +18 more
wiley +1 more source
Dysregulated lipid metabolism in kidney stone pathogenesis: a literature review of mechanistic insights and therapeutic implications. [PDF]
BMC UrolWen Q, Li Q, Zhou H, Su B, Ren Y, He Q.
europepmc +1 more source
Dupilumab Dampens Mucosal Type 2 Response During Acetylsalicylic Acid Challenge in N‐ERD Patients
Clinical &Experimental Allergy, EarlyView.Dupilumab therapy reduced elevated type 2 cytokine responses post‐ASA provocation in N‐ERD patients, independent of ASA tolerance, and revealed novel mechanistic insights by modulating acute type 2 immunity. Transcriptomic analysis showed concurrent downregulation of lipid and peroxisome pathways during ASA challenge in N‐ERD patients after 24 weeks of
Julia Eckl‐Dorna +10 more
wiley +1 more source
HDL protein composition differs between young white European and South Asian men before and after weight gain. [PDF]
Clin Sci (Lond)Beazer JD +9 more
europepmc +1 more source
Cardiovascular Health in Women—Across the Lifespan
Clinical Endocrinology, EarlyView.ABSTRACT Cardiovascular disease (CVD) remains the leading cause of mortality and morbidity among women worldwide. However, CVD continues to be perceived as a predominantly male issue. CVD in women therefore remains understudied, underrecognized and undertreated.
Jaya Chandrasekhar +5 more
wiley +1 more source
Combined Effects of Exercise and Broccoli Supplementation on Metabolic and Lipoprotein Biomarkers in Adults with Type 2 Diabetes: A Randomized Controlled Trial. [PDF]
NutrientsDelfan M +9 more
europepmc +1 more source
Dynamics of Apolipoprotein J Levels and Metabolic Parameters Following Bariatric Surgery
Clinical Endocrinology, EarlyView.ABSTRACT Objective Bariatric surgery has emerged as a potent intervention for ameliorating insulin resistance and its associated comorbidities in obese patients. Apolipoprotein J (ApoJ) and adiponectin are closely associated with insulin resistance and sensitivity, respectively.
Kellen Cristina da Cruz Rodrigues +7 more
wiley +1 more source
Effect of Guava Seeds on the Biochemical Parameters and Composition of HDL Subclasses in Ovariectomized Rats. [PDF]
Antioxidants (Basel)Ramírez-Melo LM +5 more
europepmc +1 more source
The Need to Promote Olfactory Health in Public Health Agendas Across the Globe
Clinical Otolaryngology, EarlyView.ABSTRACT Background A good sense of smell is essential for physical and mental health, and social wellbeing; however, across the globe, regardless of the setting, national public health agendas never consider smell health. This review aims to summarise the wide‐reaching impact of smell health in public health. Methods Narrative review of the literature
Carl Martin Philpott +5 more
wiley +1 more source