Results 301 to 310 of about 13,250,277 (360)

HDL Nanodiscs Loaded with Liver X Receptor Agonist Decreases Tumor Burden and Mediates Long‐term Survival in Mouse Glioma Model

Small, EarlyView.
Synthetic high‐density lipoprotein (sHDL) nanodiscs are developed to co‐deliver liver‐X‐Receptor (LXR) agonists and Toll‐like receptor 9 (TLR‐9) agonist CpG for glioma treatment. By upregulation of ATP‐binding cassette transporter A1 (ABCA1), LXR agonists synergize with sHDL nanodiscs to deplete cholesterol and induce apoptosis of glioma cells.
Troy A. Halseth, Anzar A. Mujeeb, Lisha Liu, Kaushik Banerjee, Nigel Lang, Todd Hollon, Minzhi Yu, Mark Vander Roest, Ling Mei, Hongliang He, Maya Sheth, Maria G. Castro, Anna Schwendeman   +12 more
wiley   +1 more source

Challenges and opportunities for statistical power and biomarker identification arising from rhythmic variation in proteomics. [PDF]

NPJ Biol Timing Sleep
Spick M, Isherwood CM, Gethings LA, Hughes CJ, Daly ME, Hassanin H, van der Veen DR, Skene DJ, Johnston JD.   +8 more
europepmc   +1 more source

Lipoprotein receptors: A little grease for enveloped viruses to open the lock? [PDF]

J Biol Chem
Cosset FL, Denolly S.
europepmc   +1 more source

Exploring 2D Graphene‐Based Nanomaterials for Biomedical Applications: A Theoretical Modeling Perspective

Small Science, EarlyView.
Two‐dimensional graphene‐based nanomaterials are of significant interest in biomedical applications due to their unique physicochemical properties. Computational modeling provides useful insights into their structure and interactions with biological systems, aiding the nanoparticle design.
Alexa Kamboukos, Nevena Todorova, Irene Yarovsky   +2 more
wiley   +1 more source

Potential causal evidence for an ApoB-independent and HDL-related risk profile associated with coronary artery disease. [PDF]

J Lipid Res
Ao L, van Heemst D, Jukema JW, Rensen PCN, Willems van Dijk K, Noordam R.   +5 more
europepmc   +1 more source

Systemic Brain Delivery of Oligonucleotide Therapeutics Enhanced by Protein Corona‐Assisted DNA Cubes

Small Methods, EarlyView.
In vivo, screening of DNA nanostructures yields a cube‐shaped structure (D‐Cb) as a protein corona‐assisted platform for brain delivery of oligonucleotide therapeutics. D‐Cb effectively delivers polo‐like kinase 1 (PLK‐1) antisense oligonucleotides (ASO) to treat glioblastoma in an orthotopic mouse model, demonstrating its potential as a carrier for ...
Kyoung‐Ran Kim, Ji Hee Kang, Hien Bao Dieu Thai, Ji Hyun Back, Chengde Mao, Ji Eun Lee, Young Tag Ko, Dae‐Ro Ahn   +7 more
wiley   +1 more source

Relevance of Lipoprotein Composition in Endothelial Dysfunction and the Development of Hypertension. [PDF]

Int J Mol Sci
Ramírez-Melo LM, Estrada-Luna D, Rubio-Ruiz ME, Castañeda-Ovando A, Fernández-Martínez E, Jiménez-Osorio AS, Pérez-Méndez Ó, Carreón-Torres E.   +7 more
europepmc   +1 more source

Exosome‐Based Theranostic for Gastrointestinal Cancer: Advances in Biomarker Discovery and Therapeutic Engineering

Small Methods, EarlyView.
This review explores the dual roles of exosomes in gastrointestinal (GI) cancers as diagnostic biomarkers and therapeutic agents. It highlights advancements in exosomal miRNAs, lncRNAs, circRNAs, and proteins for cancer detection and prognosis. The study also examines engineering strategies for exosome‐based drug delivery systems, their potential to ...
Mohit J. Mehta, Dongjun Shin, Hyun Sung Park, Jun Su An, Seong Il Lim, Hyun Jin Kim, Seungpyo Hong, Jiyoon Bu   +7 more
wiley   +1 more source

Understanding the heterogeneity and dysfunction of HDL in chronic kidney disease: insights from recent reviews. [PDF]

BMC Nephrol
Xu Z, Yang S, Cui L.
europepmc   +1 more source