Results 111 to 120 of about 37,409 (305)

Apolipoprotein E Polymorphism and Lipid Metabolism Disorders in Children with Cholelithiasis

Zdorovʹe Rebenka, 2016
Relevance. The incidence of cholelithiasis in children in Ukraine has increased from 0.1–1 to 4.8 % in the structure of biliary pathology [6, 9, 13]. Rising the incidence of cholelithiasis in childhood is obvious, but the reasons are not clear.
Ye.V. Shutova
doaj   +1 more source

Application of non-HDL cholesterol for population-based cardiovascular risk stratification: results from the Multinational Cardiovascular Risk Consortium. [PDF]

, 2019
BACKGROUND: The relevance of blood lipid concentrations to long-term incidence of cardiovascular disease and the relevance of lipid-lowering therapy for cardiovascular disease outcomes is unclear.
Alver, M. (Maris), Amouyel, P. (Philippe), Bakker, S.J.L. (Stephan), Benjamin, E.J. (Emelia J.), Blankenberg, S. (Stefan), Bobak, M. (Martin), Brambilla, P. (Paolo), Brenner, H. (Hermann), Brunner, F.J. (Fabian J), Costanzo, S. (Simona), Dallongeville, J., de Lemos, J.A. (James A), Dobson, A. (Annette), Donfrancesco, C. (Chiara), Drygas, W. (Wojciech), Dullaart, R.P.F. (Robin P.F.), Dörr, M. (Marcus), Eliasson, M. (Mats), Engström, G., Ferrières, J. (Jean), Giampaoli, S. (Simona), Gianfagna, F. (Francesco), Giles, G. (Graham), Grassi, G. (Guido), Hodge, A. (Allison), Hveem, K. (Kristian), Iacoviello, L. (Licia), Ikram, M.K. (M. Kamran), Ingelsson, M. (Martin), Jorgensen, T. (Torben), Jousilahti, P. (Pekka), Jääskeläinen, T. (Tuija), JöCkel, K.-H. (Karl-Heinz), Kavousi, M. (Maryam), Kee, F. (F.), Klotsche, J. (Jens), Koenig, W. (Wolfgang), Kontto, J. (Jukka), Kuulasmaa, K. (Kari), Lackner, K.J. (Karl), Landmesser, U. (Ulf), Leistner, D.M. (David M), Linneberg, A. (Allan), Lorenz, T. (Thiess), Lyngbakken, M.N. (Magnus N.), Magliano, D.J., Makarova, N. (Nataliya), Malyutina, S., Mathiesen, E.B. (Ellisiv), Meisinger, C. (Christa), Melander, O. (Olle), Metspalu, A. (Andres), Moitry, M. (Marie), Männistö, S. (Satu), Nauck, M. (Matthias), Niiranen, T. (Teemu), Nikitin, Y., Ojeda, F. (Francisco), Omland, T. (Torbjørn), Pajak, A. (Andrzej), Panagiotakos, D.B. (Demosthenes), Peters, A. (Annette), Pitsavos, C. (Christos), Riserus, U. (Ulf), Salomaa, V. (Veikko), Sans, S. (Susana), Schmidt, B. (Börge), Schöttker, B. (Ben), Shaw, J.E., Shea, S. (Steven), Signorini, S. (Stefano), Simons, L.A. (Leon), Söderberg, S. (Stefan), Tamosiunas, A. (Abdonas), Thorand, B. (Barbara), Tunstall-Pedoe, H. (Hugh), Twerenbold, R. (Raphael), Vasan, R.S. (Ramachandran Srini), Veronesi, G. (Giovanni), Völzke, H. (Henry), Waldeyer, C. (Christoph), Wannamethee, S.G. (Goya), Whincup, P.H. (Peter), Wild, P.S. (Philipp), Wilsgaard, T. (Tom), Woodward, M. (Mark), Zeller, T. (Tanja)   +86 more
core   +10 more sources

Multi‐omics data mining combined with experimental validation reveals ferroptosis‐ and autophagy‐associated hub genes as diagnostic candidates and immune modulators in atherosclerosis

Animal Models and Experimental Medicine, EarlyView.
Using the GSE225650 dataset, we performed differential expression gene (DEG) screening, Weighted Gene Coexpression Network Analysis (WGCNA), and immune infiltration profiling on atherosclerosis (AS) samples, yielding 104 shared candidate genes. Subsequently, these 104 candidate genes were intersected with ferroptosis‑ and autophagy‑related gene sets ...
Xinou Zheng, Jinling Zheng, Xuezhuang Li, Hua Chen, Li Zhang, Yuqiong Zhao, Yahao Ling   +6 more
wiley   +1 more source

Análisis del polimorfismo del gen APOE en la población de Barranquilla, Colombia

Biomédica: revista del Instituto Nacional de Salud, 2016
Introducción. La variabilidad genética del polimorfismo del gen APOE se considera un importante factor asociado a la predisposición a las enfermedades que afectan el metabolismo lipídico, a las enfermedades coronarias y a la enfermedad de Alzheimer ...
Martha Ruiz, Isis Arias, Gloria Rolón, Enio Hernández, Pilar Garavito, Carlos Silvera-Redondo   +5 more
doaj   +1 more source

Chronological Diagnostic Algorithm Predicting Neuropathology in Parkinsonism

Annals of Neurology, EarlyView.
Objective Pre‐mortem diagnosis of parkinsonism is often challenging due to atypical presentations, overlapping syndromes, and co‐pathologies. This study aimed to develop a machine learning‐based algorithm predicting neuropathology in parkinsonism using chronological clinical presentations, which has previously been underexplored.
Daisuke Ono, Hiroaki Sekiya, Alexia R. Maier, Neill R. Graff‐Radford, Zbigniew K. Wszolek, Dennis W. Dickson   +5 more
wiley   +1 more source

Polarized secretion of newly synthesized lipoproteins by the Caco-2 human intestinal cell line

Journal of Lipid Research, 1987
Lipoprotein secretion by Caco-2 cells, a human intestinal cell line, was studied in cells grown on inserts containing a Millipore filter (0.45 micron), separating secretory products from the apical and basolateral membranes into separate chambers.
M G Traber, H J Kayden, M J Rindler
doaj   +1 more source

Temporal Modeling of Amyloid and Tau Trajectories in Alzheimer's Disease Using PET and Plasma Biomarkers

Annals of Neurology, EarlyView.
Objective This study aimed to compare positron emission tomography (PET) and plasma‐based temporal modeling of amyloid and tau biomarkers in Alzheimer's disease. Methods Longitudinal amyloid PET (n = 1,097, mean age ± SD = 72.5 ± 7.38 year, 51.4% male), 18F‐flortaucipir tau‐PET (n = 230, 74.3 ± 7.18 year, 52.2% female), and Fujirebio Lumipulse plasma p‐
Christopher A. Brown, Katheryn A.Q. Cousins, Magdalena Korecka, Emily McGrew, Alice Chen‐Plotkin, John A. Detre, Corey T. McMillan, Edward B. Lee, Sandhitsu R. Das, Dawn Mechanic‐Hamilton, Paul A. Yushkevich, Ilya M. Nasrallah, Leslie M. Shaw, for the Alzheimer's Disease Neuroimaging Initiative, David A. Wolk   +14 more
wiley   +1 more source

Efflux of lipid from fibroblasts to apolipoproteins: dependence on elevated levels of cellular unesterified cholesterol.

Journal of Lipid Research, 1992
Earlier work from this laboratory showed that enrichment of cells with free cholesterol enhanced the efflux of phospholipid to lipoprotein acceptors, suggesting that cellular phospholipid may contribute to high density lipoprotein (HDL) structure and the
JK Bielicki, WJ Johnson, RB Weinberg, JM Glick, GH Rothblat   +4 more
doaj   +1 more source

Multimorbidity and Associations with Cognition and Alzheimer's Disease Biomarkers

Annals of Neurology, EarlyView.
Objective Multimorbidity, the coexistence of 2 or more chronic conditions, has been linked to cognitive aging and Alzheimer's disease (AD) and AD‐related dementias, yet the mechanisms remain unclear. We aimed to examine the associations of multimorbidity with cognition and biomarkers across multiple mechanistic pathways.
Xiaqing Jiang, Sid E. O'Bryant, Robert A. Rissman, Leigh A. Johnson, Meredith N. Braskie, Kristine Yaffe, the HABS‐HD Study Team, Sid E. O'Bryant, Kristine Yaffe, Arthur Toga, Robert Rissman, Leigh Johnson, Meredith Braskie, Kevin King, James R. Hall, Melissa Petersen, Raymond Palmer, Robert Barber, Yonggang Shi, Fan Zhang, Rajesh Nandy, Roderick McColl, David Mason, Bradley Christian, Nicole Phillips, Stephanie Large, Joe Lee, Badri Vardarajan, Monica Rivera Mindt, Amrita Cheema, Lisa Barnes, Mark Mapstone, Annie Cohen, Amy Kind, Ozioma Okonkwo, Raul Vintimilla, Zhengyang Zhou, Michael Donohue, Rema Raman, Matthew Borzage, Michelle Mielke, Beau Ances, Ganesh Babulal, Jorge Llibre‐Guerra, Carl Hill, Rocky Vig   +45 more
wiley   +1 more source

Protein heterogeneity of lipoprotein particles containing apolipoprotein A-I without apolipoprotein A-II and apolipoprotein A-I with apolipoprotein A-II isolated from human plasma.

Journal of Lipid Research, 1988
The protein heterogeneity of fractions isolated by immunoaffinity chromatography on anti-apolipoprotein A-I and anti-apolipoprotein A-II affinity columns was analyzed by high resolution two-dimensional gel electrophoresis.
R W James, D Hochstrasser, J D Tissot, M Funk, R Appel, F Barja, C Pellegrini, A F Muller, D Pometta   +8 more
doaj   +1 more source