Results 161 to 170 of about 235,111 (333)

CD4+ T Cell‐Intrinsic Arg1 Regulates Th1 Dynamics in Influenza: Functional and Translational Implications for Infection and Cancer Inflammation

Allergy, EarlyView.
Anishaa Balaji, Sophia N. Karagiannnis, Alexandra J. McCraw   +2 more
wiley   +1 more source

OSA Initiates Histone Lactylation That Drives PDE4B/FUS/AGT Axis to Pulmonary Hypertension

Cell Proliferation, EarlyView.
This study illustrates how chronic intermittent hypoxia (CIH) in obstructive sleep apnea (OSA) leads to hypertension via increased oxidative stress and mitochondrial dysfunction in pulmonary artery smooth muscle cells (PASMCs), causing glycolytic dysregulation. Lactate accumulation enhances histone lactylation, upregulating phosphodiesterase 4B (PDE4B),
Li Yang, Qing Ni, Yan He, Shijie Liu, Lulu Gan, Anni Dai, Yang Hu, Qian Liu, Xueling Yang, Jiqian Li, Yi Tao, Yunyu Li, Mingyue Xu   +12 more
wiley   +1 more source

Manned Venus Flyby [PDF]

This study is one of several being conducted at Bellcomm and in Manned Space Flight whose purpose is to give guidance to the Apollo Applications Program's technical objectives by focusing on a longer range goal.
Feldman, M. S., Ferrara, L. A., Havenstein, P. L., Volonte, J. E., Whipple, P. H.   +4 more
core   +1 more source

Mitophagy and Bip–PERK–eIF2α–ATF4 Axis‐Mediated ER Stress Mediate Miriplatin‐Loaded Liposome's Anti‐Colorectal Cancer Action

Cell Proliferation, EarlyView.
LMPt enters the cell mainly through caveolin‐mediated endocytosis, and then fuses with endosomes and lysosomes to deliver MPt to mitochondria and the endoplasmic reticulum to induce mitophagy based on the fusion of lysosomes and mitochondria, and endoplasmic reticulum stress and subsequent apoptosis via the Bip–PERK–eIF2α–ATF4 axis to exert an anti ...
Cong Zhao, Yuhan Qiu, Xiaowei Wang, Mengyan Wang, Li Liu, Xiaojun Zhao, Zixiang Gao, Rongguang Shao, Guimin Xia, Wuli Zhao   +9 more
wiley   +1 more source

Petrographic survey of lunar regolith breccias [PDF]

Regolith breccias from the Moon and from parent bodies of some meteorites may provide samples of ancient regoliths which have been frozen in time. If these rocks were essentially closed at some earlier time and that time can be determined, then these ...
Mckay, D. S., Wentworth, S.
core   +1 more source

Change in body mass index and disease burden among people with obesity and multiple long‐term conditions

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Obesity is a risk factor for multiple long‐term conditions (MLTCs/multimorbidity). However, the impact of weight loss in people with MLTCs is unclear. We investigated the association between body mass index (BMI) change and the development of obesity‐related complications (ORCs), as well as clinical and economic outcomes in individuals ...
Kamlesh Khunti, Alex Mourer, Silvia Capucci, Lua Wilkinson, Klaus K. Andersen, Abd A. Tahrani, Camilla S. Morgen   +6 more
wiley   +1 more source

A physical model of Apollo oxygen releases [PDF]

Physical model of Apollo oxygen ...
Buffalano, A. C.
core   +1 more source

Safety, feasibility, and dose‐dependent metabolic effects of endoscopic duodenal pulsed electric field therapy in adults with type 2 diabetes: Results from two multicentre proof‐of‐concept studies

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims The duodenum plays a central role in metabolic regulation, influencing insulin sensitivity, and glucose homeostasis. In type 2 diabetes (T2D), structural and functional abnormalities of the duodenal mucosa (“diabetic duodenopathy”) are increasingly recognized as contributors to insulin resistance and dysglycaemia.
David N. O'Neal, Adrian Sartoretto, Bronte A. Holt, Barham K. Abu Dayyeh, Rhys Vaughan, Georgina Cameron, Sujievvan Chandran, Alexander J. Thompson, Howard McCollister, Paul Severson, Andrew C. Storm, Lian Cunningham, Elif I. Ekinci   +12 more
wiley   +1 more source

From cognitive gap to innovation synergy: public cognitive evolution law and implications in the new unmanned-driven business model. [PDF]

Sci Rep
Zhang Y, Zhuang W.
europepmc   +1 more source

Apollo water impact Status report, 1 Oct. 1969 - 1 Mar. 1970 [PDF]

Computer program for Apollo water ...
Kettleborough, C. F.
core   +1 more source