Results 61 to 70 of about 521,681 (299)

Molecular Glue Degraders Enhance CAPRIN1-Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease. [PDF]

Adv Sci (Weinh)
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Jung S, Wang X, Liu B, Roy R, Jaiswal N, Rai RK, Takagi Y, Gao C, Zeng L, Lo HY, Wohlford RK, Higgins RK, Lamb BT, Shekhar A, Bellail AC, Hao C.   +15 more
europepmc   +2 more sources

Immediate Edge App Review – Is This Trading Software Legit?

, 2021
Immediate Edge App Cryptocurrency sphere is home to severa scam artists, it is also home to a reputedly identical style of suitable-hearted peoples who need to help others on their journey and now no longer the use of a financial reimbursement. Immediate
Immediate Edge App
core   +1 more source

PASTA‐ELN: Simplifying Research Data Management for Experimental Materials Science

Advanced Engineering Materials, EarlyView.
Research data management faces ongoing hurdles as many ELNs remain complex and restrictive. PASTA‐ELN offers an open‐source, cross‐platform solution that prioritizes simplicity, offline access, and user control. Its in tuitive folder structure, modular Python add‐ons, and open formats enable seamless documentation, FAIR data practices, and easy ...
S. Brinckmann, G. Winkens, R. Schwaiger
wiley   +1 more source

DigiChrom: A Domain Ontology for Semantic Representation of Trivalent Chromium Platings and Its Large Language Model‐Based Alignment With Multiple Mid‐Level Ontologies

Advanced Engineering Materials, EarlyView.
Digitalizing electroplating requires both domain knowledge and interoperability. This work introduces PlatOn, a domain ontology for trivalent chromium plating and coating characterization, and a hybrid pipeline that aligns it to a mid‐level reference ontology by combining eight similarity metrics with language model reasoning. Expert‐validated mappings
Janik Harter, Elena Garcia Trelles, Christoph Schweizer, Thomas Seifert, Christoph Baumer, Mahmoud Elkady, Katja Feige, Daniel Grimme, Edgar Hoffmann, Andreas Waibel, Anke Walter   +10 more
wiley   +1 more source

APP Expression in Primary Neuronal Cell Cultures fromP6 Mice during in vitro Differentiation [PDF]

, 1993
Primary neuronal cell cultures from P6 mice were investigated in order to study amyloid protein precursor (APP) gene expression in differentiating neurons.
Sandbrink, R., Masters, C. L., Beyreuther, K., König, G., Mönning, U., Dichgans, Martin   +5 more
core   +1 more source

FastNano Liquid: An Automated Platform for Small‐Angle X‐ray Scattering‐Based Materials Discovery

Advanced Engineering Materials, EarlyView.
We present FastNano Liquid, an automated small‐ and wide‐angle X‐ray scattering platform for the combined synthesis and characterization of (nano)materials. The platform is coupled to varied reactor workflows for both in situ studies of reaction kinetics and ex situ screening of synthesis conditions to support machine learning‐guided exploration ...
Pierre‐Baptiste Flandrin, Émeline Cournède, Jens Krarup, Michael Lesa, Foyzul Hasan, Amandine Séné, Arnaud Lahouati, David Benhaiem, Jérémie‐Luc Sanchez, Simon Delacroix, Thierry Gacoin, Fabienne Testard, Damien Faivre, David Carriere, Corinne Chevallard, Olivier Taché, Mark A. Levenstein   +16 more
wiley   +1 more source

Associations of cannabis use, other substances, and lifestyle choices on anxiety in medical cannabis patients across 45 days

Scientific Reports
Previous research has shown medical cannabis (MC) to help reduce anxiety for some individuals, although most studies show trends using cross-sectional designs or conduct secondary analyses of preexisting data. The present study systematically tracked 416
R. Nathan Pipitone, Benjamin Banai, Jessica Walters, Tyler Dautrich, Kelly Schuller, Martha Rosenthal, Kevin Provost, Branden Hall, Keenan Keeling   +8 more
doaj   +1 more source

The role of amyloid precursor proteins : studies using neurons generated from wild-type and mutant embryonic stem cells [PDF]

, 2006
Alzheimer′s Disease (AD) is the most common neurodegenerative disorder in elderly people. It is becoming an ever larger problem due to prolonged life-expectancies in developed countries.
Schrenk, Katrin
core   +1 more source

Wearable Smart Patches on Sustainable Chitosan With Reversible Microbial Growth‐Inhibitory Properties

Advanced Functional Materials, EarlyView.
ABSTRACT Chitosan, a polysaccharide upcycled from biowaste, has long promised sustainable, biocompatible, and antimicrobial films and devices, an appeal reinforced by its recent regulatory recognition, with several chitosan‐based antibacterial dressings gaining clearance through the Food and Drug Administration's 510(k) pathway.
Jacopo Nicoletti, Kubra Kocak, Andrea Michel, Enrico Cavarzerani, Ali Raza, Petr Rohzin, Nouha Loudhaief, Saimir Frroku, Nicolò Baldovin, Hazrat Bilal, Alvise Perosa, Maurizio Selva, Flavio Rizzolio, Luca Sbuelz, Sabrina Tamburini, Domenico De Fazio, Giovanni Antonio Salvatore   +16 more
wiley   +1 more source

DESAIN SISTEM INTELEJENSIA BISNIS PADA RANTAI PASOK PRODUK JAMU BERBASIS PENTAHO BUSINESS INTELLIGENCE

Jurnal Manajemen Industri dan Logistik, 2018
This paper designs business intelligence system for supply chain of herbal products in Indonesia. System design is done with system entity approach to obtain system attributes, conceptual system design using Businees Process Modeling Notation (BPMN) 2.0 ...
Aster Aryati, Dian Anwar
doaj   +1 more source