A blood-brain barrier model based on flexible tubes to tailor the biophysical and chemical environment for drug delivery testing. [PDF]
Alexaki M +7 more
europepmc +1 more source
Making the Case for Organ‐on‐Chip Platforms in Long‐Acting Therapeutics Development
LATs release drug from a tissue‐resident depot over weeks to months, improving adherence, but their development is hampered by preclinical models that cannot reproduce the coupled tissue processes, sustained release, local microenvironment change, interstitial transport, immune and foreign‐body responses, and clearance that govern depot performance in ...
Charlie Gowans +7 more
wiley +1 more source
Mechanism of Fluid Reabsorption in Kidney Proximal Tubule: Interplay Between Lateral Na<sup>+</sup>/K<sup>+</sup>-ATPase and AQP1 and SGLT1 Mediated Water Fluxes. [PDF]
Larsen EH, Sørensen JN.
europepmc +1 more source
Advances in cell sources, bioengineering, and manufacturing are reshaping the design of skin substitutes. This review highlights emerging strategies driving skin tissue engineering and discusses their potential to enable safer, reproducible, and clinically accessible skin substitutes for regenerative medicine.
Gilles Lemaître +7 more
wiley +1 more source
Synthesis of Hydrophobic Derivatives of Stilbenes with Improved Permeability and Limited Phase II Reactions. [PDF]
Navarro-Orcajada S +4 more
europepmc +1 more source
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari +10 more
wiley +1 more source
Silane-Modified ZIF-8/PDMS Mixed Matrix Membranes for Sorption-Selective Furfural Recovery via Pervaporation. [PDF]
Tonthanasutthivong C +4 more
europepmc +1 more source
Silicone breast implants are presented as a model system for understanding polymer permeation in vivo. Rather than representing material failure, “gel bleed” emerges from solution–diffusion transport‐mediated. By integrating polymer architecture, physicochemical transport, and biointerfacial processes, this review provides a unified framework that ...
D. Bouyer +12 more
wiley +1 more source
Assessment of dentinal fluid flow reduction following simulated brushing with desensitizing toothpastes using sub-nanoliter fluid flow measurement system. [PDF]
Kim S +4 more
europepmc +1 more source
Transient Charging of Mixed Ionic‐Electronic Conductors by Anomalous Diffusion
This article explores charge transport in mixed ionic‐electronic conductors (MIECs) through electrochemical impedance spectroscopy and transient current analysis. Focusing on PEDOT:PSS, WO3, and n‐doped PBDF, it uncovers the impact of anomalous diffusion via fractional modeling. The study reveals key correlations that deepen understanding and guide the
Heyi Zhang +9 more
wiley +1 more source

