Advanced Materials, EarlyView.Cancer‐associated NPC remodeling creates a high‐flux, low‐stringency nuclear state that supports malignant adaptation but increases mechanical fragility. Targeting the FG‐barrier or NPC scaffold may drive mechanostat failure, envelope rupture, DNA damage, and loss of nuclear integrity.
Sílvio Terra Stefanello +5 more
wiley +1 more source
Improved random hierarchical capillary bundle model for simulating the gas permeability evolution of alkali-activated concretes under thermal damage. [PDF]
Sci RepA N Omrani I +7 more
europepmc +1 more source
Advanced Materials, EarlyView.The mechanical performance of nanocellular polyetherimide cannot be explained by nanoporosity alone. It is shown that CO2 saturation and desorption leave a distinct mechanical signature in the glassy matrix before foaming. This matrix contribution provides a new route to understand and optimize the brittle to ductile transition in nanocellular polymers.
Félix Lizalde‐Arroyo +7 more
wiley +1 more source
Advanced Materials, EarlyView.A cholesterol‐conjugated lipid library enabled the identification of a ligand‐free LNP platform for efficient mRNA delivery to brain endothelial cells via systemic administration. This platform achieves selective BBB targeting without disrupting barrier integrity, and enables modulation of neuroinflammation and vascular function without requiring trans‐
Zeru Tian +7 more
wiley +1 more source
Increasing the Compositional Heterogeneity of Single-Chain Amphiphile Membranes Supported by Coacervate Cores Alters Stability and Properties of the Hybrid Protocells. [PDF]
LangmuirJoshi MP, Lee J, Chan M, Keating CD.
europepmc +1 more source
Understanding Operando Water Management in Hydroxide‐Exchange‐Membrane Fuel Cells
Advanced Materials Interfaces, EarlyView.Effective water management is vital for high‐performance hydroxide‐exchange‐membrane fuel cells. Using a custom water‐flux station, this study quantifies how membrane thickness, microporous layers, and operating conditions dictate internal water transport.
Catherine M. Weiss +4 more
wiley +1 more source
Optimization and <i>In Vivo</i> Characterization of a Series of Cbl‑b Inactive-State Inhibitors. [PDF]
ACS Med Chem LettLambrecht MJ +34 more
europepmc +1 more source
Redox‐Confined Interfacial Polymerization Enables Mechanically Robust and Self‐Adhesive Nanofilms
Advanced Materials Interfaces, EarlyView.Redox‐confined polymerization of a simple thiol monomer at a water‐organic interface generates robust freestanding films with nanoscale thickness. The resulting disulfide‐crosslinked nanofilms combine high stiffness with intrinsic adhesion to soft substrates, enabling conformal contact with artificial skin without additional functionalization.
Luana Gazzato +4 more
wiley +1 more source
In vitro modeling of inflammatory bowel diseases using a newly developed immunocompetent colon epithelial monolayer co-culture model. [PDF]
NPJ Biomed InnovLarafa I +7 more
europepmc +1 more source
Advanced Materials Technologies, EarlyView.We introduce an additively manufactured bioreactor with a perfusion flow system and integrated temperature and pH sensors for skeletal muscle tissue biofabrication. The bioreactor's performance was evaluated by assessing the viability, spreading of the myoblast cells in a printed scaffold, and contraction of the isolated murine musculi interossei ...
Lys Sprenger +9 more
wiley +1 more source