Results 91 to 100 of about 4,415,064 (273)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Colour appearance descriptors for image browsing and retrieval
, 2008 In this paper, we focus on the development of whole-scene colour appearance descriptors for classification to be used in browsing applications. The descriptors can classify a whole-scene image into various categories of semantically-based colour ...
Martinez, Kirk, Othman, Aniza
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Rapid prediction of green tea quality based on convolutional neural network [PDF]
Emirates Journal of Food and AgricultureThe appearance of tea is a core visual indicator of quality evaluation, which directly affects consumer perception and market grading. This study proposed a green tea appearance quality evaluation method based on a convolutional neural network.
Danyi Huang +4 more
doaj +3 more sources
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
THE APPEARANCE OF RUSSIAN BELIEVERS IN THE CONTEXT OF RELIGIOUS IDENTITY (ONE RESEARCH CASE)
Концепт: философия, религия, культура, 2018 The research is devoted to ideas of believers’ appearance as one of the ways of religious consciousness formation. The concept of appearance includes clothes and attributes connected with the change of personal shape.
S. V. Ryazanova
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
OPERA neutrino oscillation search: status and perspectives
, 2015 OPERA is a long-baseline experiment at the Gran Sasso laboratory (LNGS) designed to search for $\nu_\mu \rightarrow \nu_\tau$ oscillations in appearance mode. OPERA took data from 2008 to 2012 with the CNGS neutrino beam from CERN.
Galati, Giuliana
core
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source