Results 31 to 40 of about 167,455,293 (264)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Kējì Fǎxué Pínglùn, 2016 地理標示是一逐漸演進、概念多元且國際上保護機制仍有相當爭議之智慧財產權類型。現今對於地理標示之保護模式，大致可區分為以下兩者：首先是以傳統商標制度，特別是證明標章或團體商標來保護具有強烈辨識地理區域需求之地理標示，其次則是透過單獨立法之方式，賦予基於獨特地理環境而生之商品特殊保護。不論透過何者，通常會另輔以競爭法、消費者保護法、民法或其他行政規範，保護消費者不受虛假或引人錯誤標示訊息所混淆，或避免不當競爭。我國對於地理標示主要係透過傳統商標制度，特別是產地證明標章及產地團體商標 ...
許曉芬 Hsiao-Fen Hsu
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
BIO Web of Conferences, 2017 The choice of a bottle of wine is affected by the presence of attributes that are searched by consumers and can be evaluated before the purchase. The aim of the paper is to analyze the effect of some search attributes on wine price variability applying ...
Seccia Antonio +4 more
doaj +1 more source
Large-scale implementation of sustainable production practices in the Priorat-Montsant region
BIO Web of Conferences, 2019 The Priorat and Montsant Appellations of Origin are considered to produce some of the finest wines in the Mediterranean area of Spain. Located in the south of Catalonia (North-East Spain), they account for close to 4000 ha cultivated by more than 1300 ...
de la Fuente M. +6 more
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
A Contextual Analysis of Iranian Surnames in Shahnameh and Vis and Ramin [PDF]
متن شناسی ادب فارسیNaming and reputation are key factors in social recognition, a practice observed in Iran since ancient times. Examining these appellations reveals which elements each society considers important for identity and fame. This research employed an analytical-
Mehdi Rezaei, Sara Musavi
doaj +1 more source
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source
Chemoselective or Regioselective?
ChemistryEuropeOver the past two decades, there has been a notable increase in the number of reactions that have been classified as chemoselective and/or regioselective.
Andrej Kolarovič, Pavol Jakubec
doaj +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source