Results 61 to 70 of about 1,079 (265)

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

open access: yesFEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Protection of the appellation of origin under Czech law and international treatis [PDF]

open access: yes, 2013
Protection of the appellation of origin under Czech law and international treaties This thesis deals with the topic of appellation of origin. Appellation of origin is governed by Czech law, European Union law and by international multilateral and ...
Ambrož, Vladimír
core  

MARKETING TECHNOLOGIES IN CREATING THE IMAGE OF SEVASTOPOL TOURIST TERRITORY

open access: yesВестник Кемеровского государственного университета, 2015
The paper presents the marketing project of forming the image of Sevastopol tourist territory as a tourism area able to provide high quality year-round tourist and recreational services, the welfare of the local population and the preservation and ...
I. V. Zhuravleva
doaj  

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao   +6 more
wiley   +1 more source

Marijuana Appellations: The Case for Cannabicultural Designations of Origin

open access: yes, 2017
An appellation is a certified designation of origin that may also require that certain quality or stylistic standards be met. Appellations are most commonly associated with the wine industry, but they can be applied to any agricultural product for which ...
Stoa, Ryan
core  

Protection of geographical indication: a new convergence or an old divergence?

open access: yesJournal of International Economics and Management, 2016
Geographical Indications was conceptualized in the Trade-Related Aspects of Intellectual Property Rights in 1995 (TRIPs Agreement) and become one of the most contentious intellectual property rights issues in the World Trade Organization (WTO) and other ...
Thi Thu Ha Le
doaj  

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan   +9 more
wiley   +1 more source

Microsatellite analysis reveals populational structures of saccharomyces cerevisiae strains from different appellations of origin and grape varieties [PDF]

open access: yes, 2008
The objective of the present study was to evaluate populational relationships among Saccharomyces cerevisiae strains isolated from some of the Portuguese most important grapevine varieties in different appellations of origin, using polymorphic ...
Pereira, Leonor   +9 more
core  

Risk of Non‐Arteritic Anterior Ischemic Optic Neuropathy in Idiopathic Intracranial Hypertension Patients Treated with GLP‐1 Receptor Agonists

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) have demonstrated significant weight‐reducing effects and may offer benefits in idiopathic intracranial hypertension (IIH); however, recent concerns about the risk of non‐arteritic anterior ischemic optic neuropathy (NAION) have emerged.
Faisal A. Al‐Harbi   +9 more
wiley   +1 more source

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