Results 51 to 60 of about 100,554 (340)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

Four new species of Xiphocentron Brauer, 1870 (Trichoptera: Xiphocentronidae) from the Atlantic Forest, southeastern Brazil

open access: yesEuropean Journal of Taxonomy, 2018
Four new species of Xiphocentron (Antillotrichia) Brauer, 1870 from the Atlantic forest are diagnosed, described and illustrated. All of them have a small mesal sclerite and a set of spines, differing in size, density and position, on the inner face of ...
Albane Vilarino   +3 more
doaj   +1 more source

The Difficult Appendage

open access: yesAMA Journal of Ethics, 2001
Medical trivia about the ethical issues surrounding patient-requested amputations. Virtual Mentor is a monthly bioethics journal published by the American Medical Association.
openaire   +3 more sources

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

open access: yesFEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker   +8 more
wiley   +1 more source

High-resolution characterization of centriole distal appendage morphology and dynamics by correlative STORM and electron microscopy

open access: yesNature Communications, 2019
Centrioles are vital cellular structures that form centrosomes and cilia. The formation and function of cilia depends on a set of centriole’s distal appendages.
Mathew Bowler   +9 more
semanticscholar   +1 more source

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

open access: yesFEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász   +6 more
wiley   +1 more source

Successful cryoablation of an incessant atrial tachycardia arising from the right atrial appendage

open access: yesIndian Pacing and Electrophysiology Journal, 2015
The right atrial appendage can be the origin of focal atrial tachycardias. Their ablation can be challenging owing to the complexity of the appendage anatomy.
John Roshan   +3 more
doaj   +1 more source

Case Report: Application of Thoracoscopic Clamp Radiofrequency Ablation on Atrial Tachycardia Originating From Right Atrial Appendage After Catheter Ablation Failure

open access: yesFrontiers in Cardiovascular Medicine, 2021
Atrial tachycardia originating from the right atrial appendage has a higher probability of failure of catheter ablation. Here we report a case of a 13-year-old boy with incessant tachycardia, complicated by heart enlargement, and heart failure ...
Li Luo   +3 more
doaj   +1 more source

Percutaneous left atrial appendage closure vs warfarin for atrial fibrillation: a randomized clinical trial.

open access: yesJournal of the American Medical Association (JAMA), 2014
IMPORTANCE While effective in preventing stroke in patients with atrial fibrillation (AF), warfarin is limited by a narrow therapeutic profile, a need for lifelong coagulation monitoring, and multiple drug and diet interactions.
V. Reddy   +11 more
semanticscholar   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

open access: yesFEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

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