Results 221 to 230 of about 167,150 (356)

Pharmacokinetics, Pharmacodynamics, and Safety of Subcutaneous and Intravenous Garadacimab Following Single‐Dose Administration in Healthy Japanese and White Adults

open access: yesThe Journal of Clinical Pharmacology, Volume 65, Issue 4, Page 466-477, April 2025.
Abstract Garadacimab, an activated factor XII (FXIIa) inhibitor monoclonal antibody, is being evaluated for the long‐term prophylaxis of hereditary angioedema. Here, we report the results from a two‐part, phase 1, open‐label, single ascending dose study assessing the pharmacokinetics (PK), pharmacodynamics, safety, and tolerability after subcutaneous ...
Fiona Glassman   +7 more
wiley   +1 more source

Persistent Abdominal Pain and Diarrhea After Appendectomy—Crohn's Disease Versus Intestinal Tuberculosis

open access: yesJGH Open, Volume 9, Issue 4, April 2025.
ABSTRACT Case Presentation In Western Europe, intestinal tuberculosis is a rare differential diagnosis for Crohn's disease. In this report, we present a case of intestinal tuberculosis in a 59‐year‐old female initially suspected of Crohn's disease with persistent abdominal pain and diarrhea after appendectomy.
Jonas Wizenty   +2 more
wiley   +1 more source

Clinicopathological Features of Mixed Connective Tissue Disease‐Related Myositis: A Case Series

open access: yesMuscle &Nerve, Volume 71, Issue 4, Page 583-592, April 2025.
ABSTRACT Introduction Mixed connective tissue disease (MCTD) patients often have myositis, however, myopathological and clinical data for MCTD are limited. Recent reports have shown that the pathology of MCTD myositis resembles that of immune‐mediated necrotizing myopathy (IMNM), whereas earlier reports described perifascicular atrophy or inflammatory ...
Naohiro Sakamoto   +4 more
wiley   +1 more source

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