Results 121 to 130 of about 39,822 (344)
The dynamic regulation of appetitive behavior through lateral hypothalamic orexin and melanin concentrating hormone expressing cells. [PDF]
Physiol Behav, 2021 Lee J, Raycraft L, Johnson AW.
europepmc +1 more source
Animal Models and Experimental Medicine, EarlyView.Optimized dengue fever animal model: IFNAR−/− BALB/c mice with intraperitoneal injection. Background screening: Between IFNAR−/− (BALB/c, C57BL/6) and AG129 mice, IFNAR−/−BALB/c exhibited the most severe symptoms: (1) highest weight loss and clinical scores; (2) peak viremia (5.44 log10 RNA copies/mL, day 4); (3) significant organ damage (liver/brain ...
Dan Liao +9 more
wiley +1 more source
A Defense of Free-Roaming Cats from a Hedonist Account of Feline Well-being [PDF]
, 2019 There is a widespread belief that for their own safety and for the protection of wildlife, cats should be permanently kept indoors. Against this view, I argue that cat guardians have a duty to provide their feline companions with outdoor access.
E. Abbate, C.
core +3 more sources
Multimorbidity and animal models
Animal Models and Experimental Medicine, EarlyView.Multimorbidity, defined as the coexistence of ≥2 chronic conditions, is associated with aging, genetics, and environmental factors. Animal models in multimorbidity research span three tiers: simple organisms for initial screening → rodents for mechanistic analysis → large mammals for clinical prediction.
Xinpei Wang +7 more
wiley +1 more source
The Unity of the Soul in Plato's Republic [PDF]
, 2012 This essay argues that Plato in the Republic needs an account of why and how the three distinct parts of the soul are parts of one soul, and it draws on the Phaedrus and Gorgias to develop an account of compositional unity that fits what is said in the ...
Brown, Eric
core
Animal Models and Experimental Medicine, EarlyView.An 18‐month HFD successfully established a translational Macaca fascicularis model replicating key metabolic disorders (MASH, diabetes, cardiac hypertrophy). MASH was determined by liver biopsy histology, the presence steatosis, inflammatory infiltration, hepatocytic ballooning, and fibrosis were considered as MASH; diabetes was diagnosed according to ...
Hongyi Chen +12 more
wiley +1 more source
Translational PsychiatryReward processing dysfunctions e.g., anhedonia, apathy, are common in stress-related neuropsychiatric disorders including depression and schizophrenia, and there are currently no established therapies. One potential therapeutic approach is restoration of
Chenfeng Zhang +8 more
doaj +1 more source
The Role of Basolateral Amygdalar Cholinergic Neuromodulation in Emotional Learning
Journal of Integrative NeuroscienceThe basolateral amygdala (BLA) is crucial for assigning emotional valence to sensory experiences, driving approach or avoidance behaviors during subsequent encounters.
Victor Manuel Torres-Garcia +4 more
doaj +1 more source
The Sensitivity of the Crayfish Reward System to Mammalian Drugs of Abuse
Frontiers in Physiology, 2017 The idea that addiction occurs when the brain is not able to differentiate whether specific reward circuits were triggered by adaptive natural rewards or falsely activated by addictive drugs exist in several models of drug addiction.
Adam T. Shipley +5 more
doaj +1 more source
Challenges of modeling pristane‐induced lupus in non‐human primates
Animal Models and Experimental Medicine, EarlyView.Systemic lupus erythematosus (SLE) in cynomolgus monkeys was modeled by two intraperitoneal injections of pristane at a dose of 3.5 mL/kg, administered at weeks 1 and 23. Serum samples from all monkeys that received pristane tested positive for antinuclear antibodies.
Elena Vladimirovna Vinogradova +5 more
wiley +1 more source