Results 91 to 100 of about 5,896,401 (303)
Code Usage Analysis System (CUAS) [PDF]
A set of computer programs is offered to aid a user in evaluating performance of an application program. The system provides reports of subroutine usage, program errors, and segment loading which occurred during the execution of an application program ...
Horsley, P. H., Oliver, J. D.
core +1 more source
Can acquisition of expertise be supported by technology? [PDF]
, 2009 Professional trainees in the workplace are increasingly required to demonstrate specific standards of competence. Yet, empirical evidence of how professionals acquire competence in practice is lacking.
Dexter, Hilary +3 more
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
JMIR Formative ResearchBackgroundCommon interventions for musculoskeletal pain disorders either lack evidence to support their use or have small to modest or short-term effects.
Fredrik Granviken +4 more
doaj +1 more source
Methodological support to develop interoperable applications for pervasive healthcare [PDF]
, 2014 The healthcare model currently being used in most countries will soon be inadequate, due to the increasing care costs of a growing population of elderly people, the rapid increase of chronic diseases, the growing demand for new treatments and technologies, and the relative decrease in the number of healthcare professionals with respect to the ...
openaire +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Development of an Application to Support WEB Navigation [PDF]
, 2003 The Internet has evolved too rapidly, which has left us with no option but to leave many problems unsolved. In many occasions, this is due to the fact that this 'invention' was devised with a different purpose from what we understand as the Internet nowadays.
Oscar Sanjuán Martínez +4 more
openaire +1 more source
The design research pyramid: a three layer framework [PDF]
, 2007 To support knowledge-based design development, considerable research has been conducted from various perspectives at different levels. The research on knowledge-based design support systems, generic design artefact and design process modelling, and the ...
Duffy, Alexander, Wang, Wenjuan
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Developing a Web Server Platform with SAPI support for AJAX RPC using JSON [PDF]
Writing a custom web server with SAPI support is a useful task which helps students and future system architects to understand the link between network programming, object oriented programming, enterprise application designing patterns and development ...
Iulian ILIE NEMEDI
core