Results 91 to 100 of about 569,602 (292)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Optimal household energy management and participation in ancillary services with PV production [PDF]

open access: yes
The work presented in this paper deals with a project aiming to increase the value of photovoltaic (PV) solar production for residential application. To contribute to the development of the new functionalities for such system and the efficient control ...
Cédric Clastres   +3 more
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Mobile service platform competition [PDF]

open access: yes, 2012
Mobile service platforms are becoming particularly important as play a significant role in consumers' decisions to accept, adopt and use mobile services and applications.
Bouwman, Harry, Nikou, Shahrokh
core  

When Mobile Blockchain Meets Edge Computing

open access: yes, 2018
Blockchain, as the backbone technology of the current popular Bitcoin digital currency, has become a promising decentralized data management framework.
Han, Zhu   +4 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

SOURCES AND MECHANISMS OF UNIVERSAL POSTAL SERVICE FUNDING

open access: yesPerner’s Contacts, 2013
Presented paper searches optimal way of universal postal service ensuring in Czech republic. At first it is necessary to define appropriate extent and structure of universal service regarding specifics of particular state (including decision of postal ...
Libor Švadlenka, Daniel Salava
doaj  

Implementasi Web Services Sistem Integrasi Data Menggunakan Teknik Replikasi Data Pada Inventarisasi Bangunan Pemerintah [PDF]

open access: yes, 2011
S: This system prototype displays a list of government data objects, buildings, projects, construction specifications, and recapitulation of building conditions in each city/regency server which provides URL service provider and service requestor.
Ilhamsyah, I. (Ilhamsyah)
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

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