Results 171 to 180 of about 569,602 (292)

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Patient Perceptions of Blockchain-Based Health Information Exchange: User-Centered Design Study.

J Med Internet Res
Guse R, Hu S, Thiebes S, Erler C, Caridia C, Stork W, Gersch M, Sunyaev A.   +7 more
europepmc   +1 more source

A Survey on the Computing Continuum and Meta-Operating Systems: Perspectives, Architectures, Outcomes, and Open Challenges. [PDF]

Sensors (Basel)
Gkonis PK, Giannopoulos A, Nomikos N, Sarakis L, Nikolakakis V, Patsourakis G, Trakadas P.   +6 more
europepmc   +1 more source

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

An open-source JavaScript clinical neurophysiology library for education and clinical research. [PDF]

Clin Neurophysiol Pract
Lohi S, Julkunen P, Kälviäinen R, Mervaala E.   +3 more
europepmc   +1 more source

Preferences for post‐traumatic osteoarthritis prevention strategies in individuals with anterior cruciate ligament injury

Arthritis Care &Research, Accepted Article.
Objectives There is growing interest in evaluating new strategies to delay or prevent post‐traumatic osteoarthritis (PTOA) in individuals who have sustained anterior cruciate ligament (ACL) injury. This study sought to determine characteristics of potential treatments that are acceptable to patients with ACL injury.
Kevin Kennedy, Lily Waddell, Adam Easterbrook, Jeffrey N. Katz, Cale Jacobs, Morgan Jones, Faith Selzer, Elena Losina, Liana Fraenkel, Nick Bansback   +9 more
wiley   +1 more source

Merging geographic regions for the analysis of the cardiological rehabilitation care system in Hungary. [PDF]

Int J Health Geogr
Erdős M, Vassányi I, Nemes A, Kósa I.
europepmc   +1 more source

Effect of Foot Orthoses on Midfoot Pain and the Volume of Bone Marrow Lesions in the Midfoot: A Randomized Mechanism of Action Study

Arthritis Care &Research, EarlyView.
Objective Foot orthoses are thought to improve pain by potentially modifying internal mechanical forces. To test this, we explored whether foot orthoses can modify patterns of bone marrow lesions (BMLs) in people with midfoot pain. Methods Forty‐two people were recruited with midfoot pain, and magnetic resonance imaging–confirmed midfoot BMLs ...
Jill Halstead, Anne‐Maree Keenan, Philip G. Conaghan, Dennis McGonagle, Anthony C. Redmond   +4 more
wiley   +1 more source

Redesigning Telemedicine for Traditional Chinese Medicine: Service Design Approach to Digital Transformation.

JMIR Hum Factors
Jiamsanguanwong A, Luo R, Kaingam R, Kittithreerapronchai O, Authayarat W.   +4 more
europepmc   +1 more source

Attributes and levels in discrete choice experiments for pharmacy services: A systematic review to inform asthma intervention design. [PDF]

Explor Res Clin Soc Pharm
Rosyida KA, Kristina SA, Ramadona AL, Saini B.   +3 more
europepmc   +1 more source