Results 111 to 120 of about 1,180,981 (295)

Software quality and governance in agile software development

, 2009
Looking at software engineering from a historical perspective, we can see how software development methodologies have evolved over the past 50 years. Using the right software development methodology with the right settings has always been a challenge ...
Abbas, Noura
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Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

A Brain‐Wide Atlas of Astrocytic Oxytocin Receptors Reveals a Glial Basis for Nucleus Accumbens Modulation of Affiliative Behavior

Advanced Science, EarlyView.
The cellular actors of oxytocin signaling are under intense scrutiny. A brain‐wide anatomical and functional analysis in mice and rats reveals widespread expression of oxytocin receptors in astrocytes. These receptors are functionally active and, in the nucleus accumbens, selectively regulate male social affiliation.
Clémence Denis, Stefan Stojilkovic, Kai‐Yi Wang, Cristina Márquez, Annabel C. Kleinwächter, Angel Baudon, Yuval Podpecan, Aurélia Ces, Mélanie Kremer, Isabelle Arnoux, Nathalie Rouach, Jemima Helen, Sophie Trender, Andreas Wallkum, Selina Wunsch, Franziska Schommer, Moritz C. Wimmer, Tim Schubert, Felix Franke, Jabir Aliyu Muhammad, Eva M. Eisemann, Ingrid Camila Possa‐Paranhos, Cassandra Baumann, Pierre‐Alexis Derrien, Quirin Krabichler, Cosmo Garcia, Henning Fröhlich, Matthew K. Kirchner, Valery Grinevich, Pascal Darbon, Javier E. Stern, Ferdinand Althammer, Alexandre Charlet   +32 more
wiley   +1 more source

International systems and software engineering standards for very small entities [PDF]

, 2013
Very Small Entities (VSEs) developing systems or software are very important to the military since the components they develop are often integrated into products made by larger organizations. Failure to deliver a quality product on time and within budget
Gauthier Fanmuy, Gauthier Fanmuy (12620878), O'Connor, Rory, Fanmuy, Gauthier, Claude Y. Laporte, Laporte, Claude, Laporte, Claude Y., Claude Y. Laporte (12588841), O\u27Connor, Rory V., O\u27Connor, Rory, Rory V. O’Connor, Rory V. O'Connor (12588769)   +11 more
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Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation

Advanced Science, EarlyView.
VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang, Qihao Li, Kun Ye, Kezhi Liu, Mi Zhou, Minyu Chen, Lican Liao, Kangbo Huang, Zhu Wang, Qiong Deng, Jieyan Wang, Meiyu Jin, Xu Chen, Hui Liang, Jiaxing Zhang, Junhang Luo   +15 more
wiley   +1 more source

Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models

Advanced Science, EarlyView.
This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang, Yifan Dou, Yingnan Lei, Shuang Liu, Jialin Zhou, Jiaping Li, Huadong Xu, Lingfang Feng, Yongxin Li, Chuyan Zhang, Tao Li, Jianfei Wang, Xing Zhang, Xinran Wang, Luyao Liu, Jingjing Zhang, Jianlin Lou   +16 more
wiley   +1 more source

Blockchain technologies and their application in security software development

Sustainable Engineering and Innovation
Current factors like the rising frequency of cyber threats and vulnerabilities on centralized platforms indicate the inefficiency of conventional network security frameworks, leading to new solutions such as the blockchain.
Serhii Zybin, Oleg Kubrak, Petar Halachev, Yaroslav Kravchuk, Oleksandr Muliarevych   +4 more
doaj   +1 more source

Influence Factors for the Choice of a Software Development Methodology [PDF]

The success rate of software development projects can be increased by using a methodology that is adequate for the specific characteristics of those projects.
Ionel JIANU, Cristina Venera GEAMBASU, Iulia JIANU, Alexandru GAVRILA   +3 more
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Radiation‐Resistant Kr‐Selective MOF With Record Kr/Xe Selectivity at Elevated Pressure

Advanced Science, EarlyView.
ABSTRACT The separation of Kr/Xe from spent nuclear fuel off‐gas is critical, yet most current adsorbents exhibit Xe‐Kr co‐adsorption under elevated pressures, posing challenges for industrial pressure swing adsorption processes. Herein, we present and evaluate a metal‐organic framework, CALF‐20M‐w, engineered for molecular sieving separation of Kr/Xe ...
Qihang Tian, Yinhui Li, Qingkuan Meng, Shizhen Liu, Yongzheng Wang, Bin Chen, Heping Ma   +6 more
wiley   +1 more source

Inverse software configuration management [PDF]

, 1998
Software systems are playing an increasingly important role in almost every aspect of today’s society such that they impact on our businesses, industry, leisure, health and safety. Many of these systems are extremely large and complex and depend upon the
McCrindle, Rachel Jane
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