Results 121 to 130 of about 24,564,681 (283)

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

Advanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian, Shuoyao Ma, Bo Yang, Fei Gao, Hao Guo, Haixiao Liu, Xun Wu, Wenxing Cui, Jingyu Dong, Qian Lin, Yufeng Ge, Jin Ma, Jiazhen Zhao, Yongzhi Zhang, Dongzhi Xue, Jiaxin Tian, Ziwen Zhang, Kai Wang, Meng Xu, Dayun Feng, Jinpeng Zhou, Yan Qu   +21 more
wiley   +1 more source

Applying Scrum and Organizational Patterns to Multi-site Software Development

, 2007
This paper describes a pattern language for managing multi-site software projects which aims at minimizing the main problems present on the multi-site software development context. The practices and patterns of the proposed language were first identified
Cordeiro, Lucas, Becker, Cassiano, Barreto, Raimundo   +2 more
core   +1 more source

Aryl‐Tethered Pendant Sterically Shielded Imidazoliums for Durable Anion Exchange Membranes

Advanced Science, EarlyView.
An aryl‐tethered, sterically shielded imidazolium architecture protects cationic sites from hydroxide attack while avoiding vulnerable benzylic cation–polymer linkages. Incorporated into poly(arylimidazolium) membranes, this dual‐protection design enhances alkaline and oxidative durability and supports prolonged alkaline water electrolysis, offering a ...
Jinggui Lei, Lixian Wen, Xingyu Luo, Bo Wu, Wenzheng Li, Yiqi Jin, Jingbai Li, Jiantao Fan, Hui Li   +8 more
wiley   +1 more source

Linker‐Locking Strategy for the Rigidification of Flexible Metal–Organic Framework: Structural Stabilization and Controlled ESIPT for H2O/D2O Sensing

Advanced Science, EarlyView.
A linker‐locking strategy rigidifies the flexible metal–organic framework (MOF) MIL‐53‐(OH)2 via the cooperative encapsulation of ligands and structural water. This network significantly enhances the framework's aqueous stability. Crucially, rigidification suppresses enol emission to yield a single keto tautomer state with an extended lifetime ...
Amitosh Sharma, Seonghwan Lee, Seo I Park, Hak‐Won Nho, Junmo Seong, Eunseo Lee, Oh‐Hoon Kwon, Myoung Soo Lah, Jaewoong Lim   +8 more
wiley   +1 more source

Exploring IT professionals’ intention to use software development risk assessment framework [PDF]

The paper builds on the Theory of Reason Action(TRA) and Technology Acceptance Model (TAM)to develop a research model in exploring information technology (IT) professionals’ intention to use a risk assessment framework in the context of software ...
Darehshori, Elnaz Farhang, Mohamed, Norshidah   +1 more
core  

NS1‐Induced PARP1 Phase Transitions Prolongs Host Transcriptional Pausing to Promote Influenza A Virus Replication

Advanced Science, EarlyView.
After IAV infection, NS1 induces PARP1 phase transition, reducing molecular mobility in condensates, prolonging host transcriptional pause, aiding RdRp cap snatching, and promoting viral transcription. ABSTRACT Influenza A virus (IAV) commandeers host transcriptional machinery to replicate, but mechanisms remain elusive.
Shufeng Ma, Changyuan Kang, Xixian Liu, Lichao Yang, Mengyi Li, Yuting Ye, Jianfang Zhang, Yingjun Li, Guanghui Jin, Yang Liu, Xiaohong Chen, Kexin Wang, Zifeng Yang   +12 more
wiley   +1 more source

Retrospective Grid Cells in the Medial Entorhinal Cortex Encode Past Paths During Spatial Navigation

Advanced Science, EarlyView.
Retrospective grid cells are identified in the medial entorhinal cortex, with spatial firing patterns that become most grid‐like when activity is projected onto recently traversed locations. Their coding loses spatial precision in darkness and is disrupted during assisted movement, indicating that entorhinal representations incorporate recent path ...
Ruojin Liu, Xin Yuan, Zilong He, Hong Jin, Jiayi Tian, Cong Chen, Yuanjing Liu, Xiang Zhang, Shidan Wen, Emilio Kropff, Chenglin Miao   +10 more
wiley   +1 more source

Application and clinical utility assessment of natural language processing-based software for copy-number variants interpretation

Journal of Translational Medicine
Background Manual interpretation of copy-number variant (CNV) according to the guideline published by the American College of Medical Genetics and Genomics (ACMG) and the Clinical Genome Resources (ClinGen) in 2020 is labor-intensive and time-consuming ...
Songchang Chen, Chang Liu, Xiaorui Luan, Yuling Wang, Yuexin Xu, Yunshuang Li, Fenjiao Zhang, Weihui Shi, Xuanyou Zhou, Chenming Xu   +9 more
doaj   +1 more source

Influence Factors for the Choice of a Software Development Methodology [PDF]

The success rate of software development projects can be increased by using a methodology that is adequate for the specific characteristics of those projects.
Ionel JIANU, Cristina Venera GEAMBASU, Iulia JIANU, Alexandru GAVRILA   +3 more
core  

Experiments on Nonlocal Fluid‐Flow Metamaterials

Advanced Science, EarlyView.
A nonlocal fluid‐flow metamaterial composed of standard microfluidic tubes and connectors is designed. Hence, the current of the system at one position depends on the gradient of fluid flow at many other positions, leading to unusual alternating backward and forward laminar flows of water.
Ke Wang, Yi Chen, Martin Wegener
wiley   +1 more source