Results 151 to 160 of about 187,671 (216)

Pharmacogenomic profiling of the efficacy of gemcitabine monotherapy in metastatic pancreatic cancer: Subgroup analysis of the GENESECT study

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim In the GENESECT study, no significant gemcitabine (GEM) metabolism‐related germline genetic polymorphisms (GPs) were identified because approximately 70% of patients received combination therapy with nab‐paclitaxel, which has metabolic pathways different from GEM.
Takashi Yokokawa   +21 more
wiley   +1 more source

Machine Learning Models of Phase Contrast Images Predict Efficiency of Human Pluripotent Stem Cell Differentiation to Cardiomyocytes

open access: yesBiotechnology and Bioengineering, EarlyView.
Human pluripotent stem cells were differentiated to cTnT+ cardiomyocytes and imaged throughout the process using phase contrast. We predicted differentiation efficiency (cTnT+ area) from phase contrast and compared model performance with a live‐cell cTnT‐GFP reporter.
Austin K. Feeney   +6 more
wiley   +1 more source

Translating Blue Light Stimulation From Batch to Perfusion: Process and Intracellular Metabolic Analysis

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Improving cell‐specific productivity remains a central objective in biopharmaceutical manufacturing. In this study, the effect of blue light illumination on IgG1‐producing CHO DP‐12 cells was systematically evaluated across batch, fed‐batch, and perfusion cultivations in controlled 3 L bioreactor systems.
Stefanie Föller   +2 more
wiley   +1 more source

External Acoustic Meatus Approach for Ultrasonographic Evaluation of the Temporomandibular Joint: An Anatomical Validation and Proof‐of‐Concept Study

open access: yesClinical Anatomy, EarlyView.
ABSTRACT Temporomandibular disorders (TMD) represent a public health problem, affecting 31% of adults and the elderly and 11% of children and adolescents. Interest is growing in using ultrasound to evaluate the temporomandibular joint (TMJ). However, researchers need to standardize a reliable method.
Rossella Alberti   +10 more
wiley   +1 more source

Catechin and Phenolic Profiles of Fermented Miang (<i>Camellia sinensis</i> var. <i>assamica</i>) and Their Application as Natural Antioxidants in Cosmetic Formulations. [PDF]

open access: yesAntioxidants (Basel)
Sirisa-Ard P   +8 more
europepmc   +1 more source

Donor‐To‐Recipient Mean Axonal Count Ratios of Upper Limb Nerves Used in Nerve Transfer Surgery: A Systematic Review of Histomorphometric Cadaveric Studies

open access: yesClinical Anatomy, EarlyView.
ABSTRACT Nerve transfer surgery may be performed to restore sensorimotor function following peripheral nerve trauma or dysfunction. There is biological plausibility and limited correlative evidence that donor‐to‐recipient axon count ratios may impact functional outcomes.
Samuel James Ng   +4 more
wiley   +1 more source

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