Results 51 to 60 of about 3,742 (146)

SIRT7‐Mediated H2BK120 Succinylation Drives Aberrant Mitophagy in Sepsis‐Associated Cognitive Dysfunction

Advanced Science, EarlyView.
Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Na Meng, Jiateng Zhou, Xiaoyu Guo, Ting Hong, Xuelian Li, Xingyu Wei, Chanhua Zhang, Xixue Zhang, Songbin Liu, Yulin Zhang, Liangfang Yao, Lina Huang, Weidong Gu   +12 more
wiley   +1 more source

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

Advanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian, Shuoyao Ma, Bo Yang, Fei Gao, Hao Guo, Haixiao Liu, Xun Wu, Wenxing Cui, Jingyu Dong, Qian Lin, Yufeng Ge, Jin Ma, Jiazhen Zhao, Yongzhi Zhang, Dongzhi Xue, Jiaxin Tian, Ziwen Zhang, Kai Wang, Meng Xu, Dayun Feng, Jinpeng Zhou, Yan Qu   +21 more
wiley   +1 more source

Aryl‐Tethered Pendant Sterically Shielded Imidazoliums for Durable Anion Exchange Membranes

Advanced Science, EarlyView.
An aryl‐tethered, sterically shielded imidazolium architecture protects cationic sites from hydroxide attack while avoiding vulnerable benzylic cation–polymer linkages. Incorporated into poly(arylimidazolium) membranes, this dual‐protection design enhances alkaline and oxidative durability and supports prolonged alkaline water electrolysis, offering a ...
Jinggui Lei, Lixian Wen, Xingyu Luo, Bo Wu, Wenzheng Li, Yiqi Jin, Jingbai Li, Jiantao Fan, Hui Li   +8 more
wiley   +1 more source

Linker‐Locking Strategy for the Rigidification of Flexible Metal–Organic Framework: Structural Stabilization and Controlled ESIPT for H2O/D2O Sensing

Advanced Science, EarlyView.
A linker‐locking strategy rigidifies the flexible metal–organic framework (MOF) MIL‐53‐(OH)2 via the cooperative encapsulation of ligands and structural water. This network significantly enhances the framework's aqueous stability. Crucially, rigidification suppresses enol emission to yield a single keto tautomer state with an extended lifetime ...
Amitosh Sharma, Seonghwan Lee, Seo I Park, Hak‐Won Nho, Junmo Seong, Eunseo Lee, Oh‐Hoon Kwon, Myoung Soo Lah, Jaewoong Lim   +8 more
wiley   +1 more source

NS1‐Induced PARP1 Phase Transitions Prolongs Host Transcriptional Pausing to Promote Influenza A Virus Replication

Advanced Science, EarlyView.
After IAV infection, NS1 induces PARP1 phase transition, reducing molecular mobility in condensates, prolonging host transcriptional pause, aiding RdRp cap snatching, and promoting viral transcription. ABSTRACT Influenza A virus (IAV) commandeers host transcriptional machinery to replicate, but mechanisms remain elusive.
Shufeng Ma, Changyuan Kang, Xixian Liu, Lichao Yang, Mengyi Li, Yuting Ye, Jianfang Zhang, Yingjun Li, Guanghui Jin, Yang Liu, Xiaohong Chen, Kexin Wang, Zifeng Yang   +12 more
wiley   +1 more source

Retrospective Grid Cells in the Medial Entorhinal Cortex Encode Past Paths During Spatial Navigation

Advanced Science, EarlyView.
Retrospective grid cells are identified in the medial entorhinal cortex, with spatial firing patterns that become most grid‐like when activity is projected onto recently traversed locations. Their coding loses spatial precision in darkness and is disrupted during assisted movement, indicating that entorhinal representations incorporate recent path ...
Ruojin Liu, Xin Yuan, Zilong He, Hong Jin, Jiayi Tian, Cong Chen, Yuanjing Liu, Xiang Zhang, Shidan Wen, Emilio Kropff, Chenglin Miao   +10 more
wiley   +1 more source

Fractional Factorial Design-Guided Optimization of Flavonoid Content and Antioxidant Capacity in <i>Justicia gendarussa</i> Leaf Extracts and UHPLC-HRMS-Based Metabolite Characterization. [PDF]

Pharmaceuticals (Basel)
Nurcholis W, Handiani GM, Artika IM, Aisyah SI, Karadsheh G, Kurniawan A, Poór V, Marosvölgyi T, Elfiah U, Kristóf E, Arianti R.   +10 more
europepmc   +1 more source

Experiments on Nonlocal Fluid‐Flow Metamaterials

Advanced Science, EarlyView.
A nonlocal fluid‐flow metamaterial composed of standard microfluidic tubes and connectors is designed. Hence, the current of the system at one position depends on the gradient of fluid flow at many other positions, leading to unusual alternating backward and forward laminar flows of water.
Ke Wang, Yi Chen, Martin Wegener
wiley   +1 more source

Single‐Pulse Femtosecond Laser 3D Multi‐Foci Light‐Field Engineering via Multi‐Layer Noise Threshold Filtering

Advanced Science, EarlyView.
This study presents a single‐pulse femtosecond laser strategy for three‐dimensional multi‐foci light‐field shaping and high‐throughput micro/nano manufacturing. The multi‐layer noise threshold filtering algorithm improves focal quality, while the multi‐layer over‐sampling algorithm increases focal density.
Shouyu Wu, Ruiyang Wang, Lan Jiang, Mengyao Tian, Yongjiu Yuan, Junrui Wu, Liang Zhao, Ruochen Zhang, Ziqian Ning, Xin Li   +9 more
wiley   +1 more source

Optimized Ultrasound-Assisted Extraction Enhances the Recovery of Anti-Collagenase Phytochemicals from <i>Mitragyna speciosa</i> Korth. Leaves. [PDF]

Plants (Basel)
Thavanapong T, Yaowiwat N, Chaichit S, Sainakham M, Leelapornpisid P, Poomanee W.   +5 more
europepmc   +1 more source