Results 81 to 90 of about 107,802 (261)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Determining the Storage Efficiency and Deficit Coefficient for Linear Distribution of Infiltration Depths

Tikrit Journal of Engineering Sciences, 2015
This study used the definitions of irrigation systems evaluation parameters: application efficiency; application adequacy and application uniformity, in addition to the storage efficiency, the deficit coefficient and deep percolation losses.
Haki I. Yaseen
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Uniform nonsquareness and locally uniform nonsquareness in Orlicz–Bochner function spaces and applications

Journal of Functional Analysis, 2014
The notion of uniform nonsquareness is important because, if a Banach space \( X \) has this property, then it possesses the fixed point property for nonexpansive maps on closed convex and bounded subsets of \(X\). The geometry of Köthe-Bochner spaces \(E( X)\), where \(E\) is a Banach function space (also called a Köthe space) and \(X\) is a Banach ...
Shang, Shaoqiang, Cui, Yunan
openaire   +2 more sources

A New Index for Measuring the Non-Uniformity of a Probability Distribution

AppliedMath
This paper proposes a new index, the “distribution non-uniformity index (DNUI)”, for quantitatively measuring the non-uniformity or unevenness of a probability distribution relative to a baseline uniform distribution.
Hening Huang
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Performance evaluation of spraying drones compared to boom sprayers for spray applications

Scientific Reports
Spraying drones represent a recent advancement in agricultural mechanization, particularly in the domain of pesticide application. Their adoption has steadily increased due to their operational flexibility and their potential to address labor shortages ...
Mojtaba Safaeinezhad, Mahmoud Ghasemi-Nejad-Raeini, Morteza Taki   +2 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Design and Experiment of Electromagnetic Vibration Lime Spreader

Agriculture
To address the low application accuracy and poor spreading uniformity of conventional lime spreaders, an electromagnetic vibration-assisted variable-rate lime spreader integrating a shaftless screw metering mechanism was developed.
Xinge Wang, Xueguan Zhao, Xiaoyong Liao, Chunfeng Zhang, Yunbing Gao, Zhanwei Ma, Changyuan Zhai, Liping Chen   +7 more
doaj   +1 more source