Results 61 to 70 of about 146 (117)

AI‐Driven Synthesis in Medicinal Chemistry: Integrating Large Language Models, Robotic Automation, and Sustainability Metrics to Accelerate Drug Discovery

open access: yesMedicinal Research Reviews, Volume 46, Issue 6, Page 1798-1823, November 2026.
ABSTRACT Artificial intelligence (AI) is transforming synthetic chemistry from task‐specific predictors into integrated platforms that unify retrosynthesis, reaction optimization, and closed‐loop robotic automation. This review highlights how AI‐assisted planning and robotic execution shorten cycle times, reduce step counts, and improve route ...
Amit Gangwal, Antonio Lavecchia
wiley   +1 more source

<div> Self-Referential Ignorance (SRI):&nbsp; </div> <div> A Unified Information-theoretic and Computational Framework for Epistemic Limits in Embedded Systems </div>

open access: yes
We propose Self-Referential Ignorance (SRI), a unified formal framework characterizing irreducible epistemic limits in embedded, self-modeling agents operating within dynamical systems. SRI integrates computability theory, information theory, and complex
Angelito Malicse
core   +1 more source

Accelerating Mission Engineering: Evidence of a Stratified Landscape and a Path Toward Unified Practice

open access: yesSystems Engineering, Volume 29, Issue 6, Page 1120-1135, November 2026.
ABSTRACT Mission Engineering is maturing as a Systems Engineering discipline, yet adoption of its common frameworks remains stratified. This study examines whether selective adoption is observable across ME scholarship and develops a framework to address identified barriers.
James Moreland   +4 more
wiley   +1 more source

Robust CDF‐Filtering of a Location Parameter

open access: yesJournal of Time Series Analysis, Volume 47, Issue 6, Page 1113-1123, November 2026.
ABSTRACT This paper introduces a novel framework for designing robust filters associated with signal plus noise models having symmetric observation density. The filters are obtained by a recursion where the innovation term is a transform of the cumulative distribution function of the residuals.
Leopoldo Catania   +2 more
wiley   +1 more source

Robust Estimation and Inference for Time‐Varying Unconditional Volatility

open access: yesJournal of Time Series Analysis, Volume 47, Issue 6, Page 1139-1152, November 2026.
ABSTRACT We derive a general and robust estimator of a large class of parametric specifications of time‐varying unconditional volatility of financial returns, both univariate and multivariate, and establish the Consistency and Asymptotic Normality (CAN) of the estimator.
Adam Lee   +2 more
wiley   +1 more source

Extra hidden states under emission misspecification in hidden Markov models

open access: yesStatistica Neerlandica, Volume 80, Issue 4, November 2026.
Abstract Additional states in a hidden Markov model (HMM) can compensate for restrictive emission distributions without representing additional scientific regimes. We study this distinction using the established representation of mixture components as refined states.
Aurélien Nicosia
wiley   +1 more source

Evaluating Machine Learning Affinity Prediction Methods on Novel Lead Optimization Data: A 15‐PGDH Case Study

open access: yesChemMedChem, Volume 21, Issue 20, 28 October 2026.
Machine‐learning‐based protein–ligand affinity prediction has the potential to meaningfully impact drug discovery given their speed relative to traditional physics‐based methods. This case study considers recently disclosed inhibitors of 15‐hydroxyprostaglandin dehydrogenase and highlights the fragility of the domain of applicability of two methods ...
Alexander S. Rich   +2 more
wiley   +1 more source

Analog Computation and Function Algebras

open access: yes, 2009
International audienceThe first theoretical study of analog computation was published by Shannon in 1941. In this article he proposed the GPAC (General Purpose Analog Computer) as a model for the differential analyzer.
Gomaa, Walid
core   +1 more source

Bounded Immunity and Btt-Reductions

open access: yes, 1999
We define and study a new notion called k-immunity that lies between immunity and hyperimmunity in strength. Our interest in k-immunity is justified by the result that # # does not k-tt reduce to a k-immune set, which improves a previous result by ...
Stephen Fenner, Marcus Schaefer
core  

Mathematisches Forschungsinstitut Oberwolfach Report No. 52/2006 Mini-Workshop:

open access: yes, 2006
. This is a collection of extended abstracts of a mini-workshop “Logic, Combinatorics and Independence results ” that took place on November 25 – December 2, 2006 in Oberwolfach.
Andrey Bovykin (liverpool   +2 more
core  

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