Results 11 to 20 of about 14,185 (203)

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

On the Structure of SO(3): Trace and Canonical Decompositions

open access: yesMathematics
This paper is devoted to some selected topics of the theory of special orthogonal group SO(3). First, we discuss the trace of orthogonal matrices and its relation to the characteristic polynomial; on this basis, the partition of SO(3) formed by ...
Demeter Krupka, Ján Brajerčík
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Geometric analysis of slant timelike-ruled surfaces and Bertrand offsets in Minkowski 3-space

open access: yesAIP Advances
This study investigates the geometric properties of slant timelike-ruled surfaces and their Bertrand offsets in Minkowski space. By deriving their parametric equations, we examine the structural characteristics of these surfaces and classify their offset
Areej A. Almoneef, Rashad A. Abdel-Baky
doaj   +1 more source

On the comparative analysis for the fractional solitary wave profiles to the recently developed nonlinear system

open access: yesAin Shams Engineering Journal
We study the comparative exact solutions of the Kairat-II equation describing the physical behaviors of nonlinear systems. The newly introduced Kairat equation has numerous applications in the fields of plasma physics, optical communications ...
Usman Younas   +4 more
doaj   +1 more source

Editorial: Special Issue on Analytical and Approximate Solutions for Numerical Problems

open access: yesWalailak Journal of Science and Technology, 2014
Though methods and algorithms in numerical analysis are not new, they have become increasingly popular with the development of high speed computing capabilities.
Walailak Journal of Science and Technology
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Geometry of Torsion Gerbes and Flat Twisted Vector Bundles

open access: yesAxioms
Gerbes and higher gerbes are geometric cocycles representing higher degree cohomology classes, and are attracting considerable interest in differential geometry and mathematical physics.
Byungdo Park
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

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