Results 111 to 120 of about 89,296 (286)

Synergistic antiviral activity against human adenovirus through combination of itraconazole and brincidofovir

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Human adenovirus (HAdV) causes respiratory or gastrointestinal tract infections depending on the virus subtype. While HAdV infections are generally self‐limiting in immunocompetent people, they can result in significant morbidity and mortality in immunocompromised adults and children.
Mohamed Zamzamy   +16 more
wiley   +1 more source

Unified Approach in the DSS Development Process [PDF]

open access: yesInformatică economică, 2007
The structure of today's decision support environment become very complex due to new generation of Business Intelligence applications and technologies like Data Warehouse, OLAP (On Line Analytical Processing) and Data Mining.
doaj  

Divergence in μ and δ opioid receptor pharmacology in neurons and antinociceptive efficacy in neuropathic pain: Insights from MP135 and CYM51010

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and purpose Opioids targeting the μ opioid receptor remain largely ineffective in neuropathic pain conditions, emphasizing the need for novel therapeutic strategies. MP135 was reported to reduce thermal nociception in naive animals by activating μ‐δ opioid receptor heteromers.
Perrine Inquimbert   +13 more
wiley   +1 more source

Multi-agent systems for collective management of a northern Thailand watershed : model abstraction and design [PDF]

open access: yes, 2005
Scarce farmland and water resources in the highland watersheds of northern Thailand coupled with multiple users and desires have led to conflicts among stakeholders who play important roles in the system dynamics.
Ekasingh, Benchaphum   +3 more
core  

Profiling of HCAR1 signalling reveals Gαi/o and Gαs activation without β‐arrestin recruitment and the discovery of an allosteric agonist

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Lactate, historically viewed as a metabolic by‐product, has emerged as a signalling molecule via the G protein–coupled receptor Hydroxycarboxylic Acid Receptor 1 (HCAR1). The receptor is primarily expressed in adipocytes but also found in various other tissues.
Simon Lind   +6 more
wiley   +1 more source

JSClassFinder: A Tool to Detect Class-like Structures in JavaScript [PDF]

open access: yes, 2015
With the increasing usage of JavaScript in web applications, there is a great demand to write JavaScript code that is reliable and maintainable. To achieve these goals, classes can be emulated in the current JavaScript standard version. In this paper, we
Anquetil, Nicolas   +5 more
core   +3 more sources

Representing WSDL with extended UML

open access: yesRevista Colombiana de Computación, 2004
Web services are emerging to provide a systematic and extensible framework for interactions of applications, built on existing Web protocols and based on open XML standards.
Valeria de Castro   +2 more
doaj  

UML design for access control architecture in smart building application [PDF]

open access: bronze, 2023
Mariam Chaabane   +2 more
openalex   +1 more source

Human FASTK preferentially binds single‐stranded and G‐rich RNA

open access: yesThe FEBS Journal, EarlyView.
Although FASTK is known to play a role in mRNA biology, the mechanism through which it recognizes RNA has yet to be unraveled. Here, we used purified human FASTK to characterize its RNA‐binding properties in vitro. We found that FASTK prefers ssRNA oligonucleotides containing guanines with the potential to form G‐quadruplexes and binds robustly to any ...
Daria M. Dawidziak   +7 more
wiley   +1 more source

Evolutionary divergence and functional insights into the heteromeric cis‐prenyltransferase of Paramecium tetraurelia

open access: yesThe FEBS Journal, EarlyView.
Heteromeric cis‐prenyltransferases (CPT) are indispensable for dolichol synthesis and protein N‐glycosylation in most eukaryotes. The catalytic subunits are strongly conserved throughout evolution, in contrast to the evolutionarily variable accessory subunits. The POC1 protein from Paramecium tetraurelia is the smallest identified CPT‐accessory subunit
Agnieszka Onysk   +8 more
wiley   +1 more source

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