Results 131 to 140 of about 89,296 (286)

Limited roles of the miR‐17‐92 cluster in the regulation of T‐cell apoptosis

open access: yesThe FEBS Journal, EarlyView.
The pro‐apoptotic protein BIM shapes T‐cell survival and function, but how it is regulated remains unclear. In a mouse model lacking direct miR‐17‐92:Bim interactions, we observed a moderate reduction in Th17 CD4+ T cells. BIM levels were modestly increased in double‐positive thymocytes and naive CD8+ T cells, but this did not affect overall T‐cell ...
Katharina Hoppe   +7 more
wiley   +1 more source

Phycocyanobilin biosynthesis in Galdieria sulphuraria requires isomerization of phycoerythrobilin synthesized by bilin reductases

open access: yesThe FEBS Journal, EarlyView.
The biosynthesis of bilins, tetrapyrroles essential for light harvesting and sensing, is performed by specific enzymes (FDBRs). In Galdieria sulphuraria, both phycobiliprotein types bind phycocyanobilin, despite lacking the canonical synthesizing gene PCYA. Instead, PEBA and PEBB are encoded, producing phycoerythrobilin, proposed to be later isomerized
Federica Frascogna   +4 more
wiley   +1 more source

Tulsa: A Tool for Transforming UML to Layered Queueing Networks for Performance Analysis of Data Intensive Applications

open access: yesInternational Conference on Quantitative Evaluation of Systems, 2017
Chen Li   +4 more
semanticscholar   +1 more source

Regulation of PHOX2B gene expression by the long non‐coding natural antisense RNA PHOX2B‐AS1

open access: yesThe FEBS Journal, EarlyView.
PHOX2B is a transcription factor essential for autonomic nervous system development. We identify and characterize PHOX2B‐AS1, a human long non‐coding antisense transcript at the PHOX2B locus, along with its murine counterpart. Our findings reveal bidirectional transcription and reciprocal regulation: PHOX2B activates PHOX2B‐AS1, whereas PHOX2B‐AS1 ...
Simona Di Lascio   +12 more
wiley   +1 more source

Extracellular vesicles released from melanoma cells constitutively expressing MHC class II promote immune evasion and cancer progression

open access: yesThe FEBS Journal, EarlyView.
Here, we report the role of extracellular vesicles (EVs) released from melanoma cells constitutively expressing MHC class II in the regulation of immune cell functions and melanoma metastasis. In particular, we observed an increased localization of HLA‐DRα, CAM receptors, PD‐L1, and STAT3 signaling proteins in the EVs.
Francesca Costantini   +4 more
wiley   +1 more source

Automated Reverse Engineering of UML Sequence Diagrams for Dynamic Web Applications

open access: yesInternational Conference on Software Testing, Verification and Validation Workshops, 2009
Manar H. Alalfi, J. Cordy, T. Dean
semanticscholar   +1 more source

Districting in last‐mile delivery with stochastic customers

open access: yesInternational Transactions in Operational Research, Volume 33, Issue 3, Page 1636-1655, May 2026.
Abstract Due to the peculiarities of city streets, last‐mile logistics is typically organized using territory‐based routing approaches, which divide the city into a set of districts and assign drivers to deliver in one or more of them. This allows drivers to develop a deep understanding of the characteristics of each district, and clients benefit from ...
Maria Elena Bruni   +3 more
wiley   +1 more source

Design Thinking and Learning Analytics: Involving Students in Designing a Feedback Tool From Ideation to Deployment

open access: yesJournal of Computer Assisted Learning, Volume 42, Issue 1, February 2026.
ABSTRACT Background Learning analytics (LA) aim to support informed decision making based on educational data but often fail to align with students' realities, especially when designed to be used across multiple courses (e.g., interactions with feedback from multiple educators).
Bhagya Maheshi   +6 more
wiley   +1 more source

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