Results 41 to 50 of about 87,331 (292)

Mitochondrial fatty acid oxidation is stimulated by red light irradiation

FEBS Letters, EarlyView.
Light at different wavelengths has distinct effects on keratinocyte viability and metabolism. UVA light abrogates metabolic fluxes. Blue and green light have no effect on metabolic fluxes, while red light enhanced oxidative phosphorylation by promoting fatty acid oxidation. Keratinocytes are the primary constituents of sunlight‐exposed epidermis.
Manuel Alejandro Herrera, Camille C. Caldeira da Silva, Maiza Von Dentz, Mauricio S. Baptista, Alicia J. Kowaltowski   +4 more
wiley   +1 more source

An Automated Functional Testing Framework for Context-Aware Applications

IEEE Access, 2018
In the modern era of mobile computing, context-aware computing is an emerging paradigm due to its widespread applications. Context-aware applications are gaining increasing popularity in our daily lives since these applications can determine and react ...
Aamir Mehmood Mirza, Muhammad Naeem Ahmed Khan   +1 more
doaj   +1 more source

Applying Model-Driven Engineering to Distributed Ledger Deployment

IEEE Access, 2020
Distributed Ledger Technology (DLT) enables data storage in a decentralized manner among collaborating parties. The software architecture of such solutions encompasses models placed in the relevant architectural views.
Tomasz Gorski, Jakub Bednarski
doaj   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Efficient IoT-Based Formal Model for Vehicle-Life Interaction in VANETs Using VDM-SL

Energies, 2022
VANETs have gained much attention from both industry and academia because of their characteristics, such as dynamic topology. There are various applications of VANETs that are classified on the basis of safety, efficiency, commercial usage, and ...
Sidra Iqbal, Nazir Ahmad Zafar, Tariq Ali, Eman H. Alkhammash   +3 more
doaj   +1 more source

Mapping UML Sequence Diagram into the Web Ontology Language OWL

International Journal of Advanced Computer Science and Applications, 2020
—In this paper, we propose a new mapping technique from the OMG’s UML modeling language into the Web Ontology Language (OWL) to serve the Semantic Web.
Mo’men Elsayed, Nermeen Elkashef, Y. Hassan   +2 more
semanticscholar   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Towards a UML profile for modeling WAP applications

Journal of Computer Science and Technology, 2005
UML (Unified Modeling Language) is one of the most used languages to specify and document informatics applications. However, UML is a generalpurpose language, so it often lacks of elements to model and represent concrete concepts of specifics domains. As
Ricardo Soto De Giogis, Mauricio Cámara Joui   +1 more
doaj  

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source