Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Correction: Gorr, S.-U. Targeted Modification of the Antimicrobial Peptide DGL13K Reveals a Naturally Optimized Sequence for Topical Applications. Microorganisms 2025, 13, 2355. [PDF]
Gorr SU.
europepmc +1 more source
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Two-Dimensional Materials: From Synthesis to Applications, 2nd Edition. [PDF]
Wang S, Hung NT, Sun M.
europepmc +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
The role of smartphone-based functional metrics in pain medicine. [PDF]
Silva-Ortiz VM +4 more
europepmc +1 more source
Contemporary clinical applications of venous excess ultrasound: A scoping review protocol. [PDF]
Hassan S, Hassan A.
europepmc +1 more source
THE APPLICATION OF SCIENCE AND ENGINEERING TO FORESTRY
openaire +1 more source
Animal Venoms for Drug Discovery: A Constantly Evolving Research Field. [PDF]
Fajloun Z, Roufayel R, Rima M.
europepmc +1 more source
Publisher Correction: Population genetic diversity and natural Wolbachia infection in Aedes aegypti from Pakistan. [PDF]
Khan J +6 more
europepmc +1 more source

