Results 71 to 80 of about 4,460 (258)

Applicative metonymy

open access: yesRussian Language Studies, 2008
Present article is the fragment of a study of the nature of the index demonstration of means in different code systems of Russian lingvokulture context.
V A Romanenko
doaj  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

-(k)i eta -ra

open access: yesAnuario del Seminario de Filología Vasca "Julio de Urquijo", 2012
In this paper, I will propose that the Basque inflectional morpheme -(k)i is an applicative morpheme which 'applies' (dative) object arguments to the structure.
Beatriz Fernández
doaj  

Applicative Approach to Risk Management [PDF]

open access: yesRevista de Management Comparat International, 2011
Order, symmetries, correspondences and proportionalities that served as hypothesis for any economical theories are frequently infirmed by the contemporary reality.
Dumitru MIRON   +2 more
doaj  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Applicative Linguistic Knowledge and Translation

open access: yesRussian Language Studies, 2014
The article defines the notion “applicative linguistic knowledge” and shows the main objectives of teaching foreign languages. Basing on the examples of verbal communication in different subject areas, the authors propose methods of teaching analysis of ...
V I Ershov, N Yu Nelyubova, A L Semyonov
doaj  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

MANAGING CHANGE: SOME THEORETICAL AND APPLICATIVE ASPECTS [PDF]

open access: yesAnnals of the University of Oradea: Economic Science, 2012
The strategic organizational change aims is the change of procedures and systems, organizational structures and responsibilities but especially acquiring new knowledge and skills.
Botezat Elena
doaj  

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