Results 121 to 130 of about 87,331 (301)

Targeting the Spliceosomal Protein USP39 Through Allosteric Ligands and PROTAC‐Induced Degradation

open access: yesAngewandte Chemie International Edition, EarlyView.
Proteolysis‐targeting chimeras (PROTACs) enable degradation of proteins previously considered undruggable by harnessing the cellular ubiquitin–proteasome system. In this study, Schäfer et al. identify thiazole‐based small molecules that allosterically bind the zinc finger domain of ubiquitin‐specific protease 39 (USP39), a non‐enzymatic scaffold ...
Daniel Schäfer   +11 more
wiley   +1 more source

Enhancing the creative thinking for students of the Department of interior design and furniture through the use of mental maps

open access: yesJournal of Architecture, Art & Humanistic Science
Mind maps are an expressive means of ideas and schemes instead of being limited to words only, and it is a form of visual thinking, which is one of the higher levels of thinking. This method is the actual method used by the human mind to think, as we may
Prof. Doaa Abdel-rahman mohamed Professor at Interior Design & Furniture Department – Faculty of Applied Arts – Helwan University   +1 more
doaj   +1 more source

High‐Pressure Synthesis of Antimony Nitride Sb3N5 and Polynitride Sb2N8 Featuring Single‐Bonded N810− Chains

open access: yesAngewandte Chemie International Edition, EarlyView.
High‐pressure reactions between Sb and molecular nitrogen in a laser‐heated diamond anvil cell led to the formation of oC32‐Sb3N5 (51(1) GPa) and mP20‐Sb2(N8), (> 100 GPa). Both phases were identified by single‐crystal x‐ray microdiffraction and are fully corroborated by density functional theory calculations.
Lukas Brüning   +8 more
wiley   +1 more source

Dibenzazepine Bridged Network Polymeric Phthalocyanines as Degradable Heterogeneous Photocatalysts

open access: yesAngewandte Chemie International Edition, EarlyView.
Dibenzazepine photodynamic bridge has been introduced to zinc and cobalt networks phthalocyanines (NP‐Pcs) to obtain degradable heterogeneous photocatalysts. For the first time, light irradiation plays a key role in “design, use and degradation” of NP‐Pcs.
Erem Ahmetali   +4 more
wiley   +1 more source

Acquisitions: Twentieth-Century Fine and Applied Arts

open access: yesThe Rijksmuseum Bulletin, 2019
Pim Arts   +6 more
doaj   +1 more source

The Role of Awareness Advertising Message Included in ADHD Children's Interactive Clothing in Improving their Psychomotor Disorders

open access: yesMaǧallaẗ Al-Turāṯ wa Al-Taṣmīm
(ADHD) is a chronic condition that affects millions of children and often persists into adulthood. ADHD Children are always looking for things to interact with.
Dr. Basma Reda El-Fanagely   +1 more
doaj   +1 more source

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