Results 101 to 110 of about 2,779,436 (352)
L’approche phénoménologique en urbanisme : la recherche d’une meilleure pratique, la pratique d’une meilleure recherche [PDF]
Les Ateliers de l’Ethique, 2010 In urban planning, the phenomenological approach focuses on personal experiences and, more precisely, on the study of the person–environment relationship.
Sandra Breux, Juan Torres
doaj
Новые дизайны этического знания Обзор конференции «Теоретическая и прикладная этика: традиции и перспективы» [PDF]
, 2015 The review highlights the 5th all-Russian conference "Theoretical and Applied Ethics", which was held on 21-23 November 2013, at St. Petersburg University (supported by the Department of Ethics).
Гусев, Dmitriy Gusev, Дмитрий Алексеевич
core +1 more source
On Behalf of a Bi-Level Account of Trust [PDF]
, 2019 A bi-level account of trust is developed and defended, one with relevance in ethics as well as epistemology. The proposed account of trust—on which trusting is modelled within a virtue-theoretic framework as a performance-type with an aim—distinguishes ...
Carter, J. Adam
core +2 more sources
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Ethics outside, within or beyond OR models [PDF]
Since ethical concerns are calling for more attention within Operational Research, we present three approaches to combine Operational Research models with ethics.
Luk N. Van Wassenhove, Marc Le Menestrel
core
Defining the Authenticity in Authentic Leadership [PDF]
, 2013 Leadership is an expansive term with many definitions and applications. Over the years, adjectives have been applied in an effort to further define and narrow its scope and application, i.e., transactional, transformational, and servant.
Bishop, William H
core +2 more sources
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Science and Engineering Ethics, 2010 This paper explores the relationships that various applied ethics bear to each other, both in particular disciplines and more generally. The introductory section lays out the challenge of coming up with such an account and, drawing a parallel with the philosophy of science, offers that applied ethics may either be unified or disunified.
openaire +3 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Plaidoyer pour un élargissement des pratiques de l’éthique de la recherche [PDF]
Les Ateliers de l’Ethique, 2007 In North America, Canada and Québec, the practice of research ethics is articulated around the application by local authorities of certain principles and application rules found in normative documents. This framework aims to evaluate research projects in
Isabelle Boutin-Ganache
doaj