Results 21 to 30 of about 67,535 (223)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
EnergiesThis paper explores the factors influencing regions’ commitment to the EU’s green energy transition during the 2021–2027 period, with a particular focus on the impact of prior commitments and fossil fuel dependence.
Korneliusz Pylak +2 more
doaj +1 more source
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
FEBS Open Bio, EarlyView.Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
MathematicsThis paper introduces an application of the Chatterjea–Singh fixed-point theorem to nonlinear boundary value problems (BVPs). We define a Chatterjea–Singh mapping as one whose iterate Tp satisfies a Chatterjea-type contractive condition.
Zouaoui Bekri +3 more
doaj +1 more source
Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova +9 more
wiley +1 more source
MathematicsIn this paper, we introduce and investigate two generalized forms of classical contraction mappings, namely the p-Hardy–Rogers and p-Zamfirescu contractions.
Zouaoui Bekri +3 more
doaj +1 more source
Convex geometries yielded by transit functions [PDF]
Opuscula MathematicaLet \(V\) be a finite nonempty set. A transit function is a map \(R:V\times V\rightarrow 2^V\) such that \(R(u,u)=\{u\}\), \(R(u,v)=R(v,u)\) and \(u\in R(u,v)\) holds for every \(u,v\in V\).
Manoj Changat +3 more
doaj +1 more source