Results 101 to 110 of about 313,173 (254)

Dysregulation of Oral Microbial Eicosapentaenoic Acid Induced by Chronic Restraint Stress Exacerbates Periodontitis via M1 Macrophage Polarization

Advanced Science, EarlyView.
ABSTRACT The intricate interplay between chronic psychological stress and periodontitis, mediated by oral microbiota and macrophage polarization, remains largely enigmatic. Here, we demonstrate that chronic restraint stress (CRS) exacerbates periodontitis by inducing oral microbial dysbiosis and a consequential shift in host metabolism.
Shihong Luo, Fangzhi Lou, Peiran Yang, Yu Zhang, Li Yan, Yunmei Dong, Bing Yang, Haiyang Wang, Yiyun Liu, Juncai Pu, Richard D. Cannon, Peng Xie, Ping Ji, Xin Jin   +13 more
wiley   +1 more source

Piezo1 Channel Mediates Mechanically Programmable Drug Delivery to Potentiate Intravesical Chemotherapy

Advanced Science, EarlyView.
This study utilizes programmable mechanical pressure as a therapeutic enhancer to establish a mechano‐chemotherapy strategy. Controlled pressure activates the mechanosensitive ion channel Piezo1 in bladder cancer, triggering a calcium ion cascade that transiently and reversibly amplifies membrane permeability to chemotherapeutics.
Minghai Ma, Xing Li, Minxuan Jing, Zezhong Yang, Jiale He, Jianpeng Li, Xiao Liang, Yunzhong Jiang, Rou Huang, Yuanquan Zhang, Yuanchun Pu, Jiawei Xiu, Yutong Chen, Kaibo Mi, Pu Zhang, Lei Wang, Jinhai Fan   +16 more
wiley   +1 more source

Wearable Cooling Textiles of Thermal Conduction and Sweat Transfer for Personal Thermal Management

Advanced Science, EarlyView.
This study constructs a three‐dimensional thermal‐conductive pathway using biomass‐based fibers. The thermally conductive composite fibers were designed into Janus‐structured fabrics. The wearable cooling textile exhibits unidirectional moisture‐wicking properties (476% index), a high water evaporation rate (5209.92 g/m2/day), and effective skin ...
Jiajing Zhang, Jiahao Xu, Chunhua Zhang, Liangjun Xia, Xin Liu, Weilin Xu   +5 more
wiley   +1 more source

18β‐Glycyrrhetinic Acid and a Nano‐Liposomal Formulation Alleviate Depression‐Like Behaviors via the Microglial mTOR‐Autophagy‐NLRP3 Axis

Advanced Science, EarlyView.
Using a novel zebrafish‐based inflammatory screening strategy, we screened and identified 18β‐glycyrrhetinic acid (18β‐GA) as a promising anti‐inflammatory candidate. We uncover a microglial mTOR–autophagy–NLRP3 axis that constitutes the mechanistic core of 18β‐GA–mediated neuroprotection.
Hua Gan, Haitao Yuan, Wenjun Zhu, Xiaokang Xie, Shen Zhou, Wenzhi Hao, Xiaowei Mo, Lian Yang, Xiaojuan Li, Junshan Liu, Lijuan Deng, Jiaxu Chen   +11 more
wiley   +1 more source

Synergies in Agricultural Biodiversity Conservation: Decomposing the Interaction Between Nature Parks and Agri‐Environment Schemes

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT Understanding how policy instruments with overlapping goals interact is crucial for leveraging their synergies. This study explores the mechanisms for regional nature parks (a form of protected areas that impose no restrictions on agriculture) to enhance the adoption of biodiversity‐conserving agri‐environment schemes (AES) in Switzerland ...
Yanbing Wang, Christian Ritzel, Antonia Kaiser, Gabriele Mack   +3 more
wiley   +1 more source

Rethinking Power Solutions for Healthcare Wearables: From Point‐of‐Care and Episodic use to Continuous Monitoring and Therapeutic Platforms

Advanced Energy and Sustainability Research, EarlyView.
This Perspective examines practical power solutions for wearable healthcare systems, highlighting the limits of standard batteries. It categorizes wearables into four domains—point‐of‐care diagnostics, episodic monitoring, continuous long‐term monitoring, and therapeutic platforms—and analyzes their power needs.
Seokheun Choi
wiley   +1 more source

Hainan Longevity Model, Senile Degeneration, Cognitive Disability and Healthy Longevity

AGING MEDICINE, EarlyView.
Investigating centenarians who exemplify healthy longevity can aid in formulating preventive strategies aimed at achieving health and extending lifespan in the context of population aging. Hainan longevity model (HLM) plays key roles in promoting healthy longevity and provides scientific evidence for achieving healthy longevity in the older population.
Shihui Fu, Jiacai Lin, Qianshuo Liu, Lianbo Gao, Zhirui Li, Feng Lin, Leixing Xie, Xiong Liu, Wenkai Xiao, Qiwei Zhu, Fan Wang, Jin Zheng, Yali Zhao, Xiaolei Chen, Yao Yao, Long Feng   +15 more
wiley   +1 more source

Prevalence and Correlates of Geriatric Depression: A Community‐Based Cross‐Sectional Study in Bangladesh

AGING MEDICINE, EarlyView.
Geriatric depression affects over one‐third of older adults in Bangladesh. Poor family bonding, financial instability, lifestyle dissatisfaction, chronic illness, and lack of exercise are key contributors, underscoring the urgent need for integrated mental health support and social interventions for the aging population.
Md. Biplob Hossain, Md. Imdadul Haque, Md. Monir Hossain Shimul, Rebeka Jesmin Sarker, Syed Nazmus Sakib, Ajahar Islam Hridoy, Kausar Ahammed Nishat, Foysal Ahmed, Mohammed Nadir Bin Ali, Hafiz T. A. Khan, Salim Khan, ABM Alauddin Chowdhury   +11 more
wiley   +1 more source

Chinese Expert Consensus on Immune Checkpoint Inhibitor Therapy for Elderly Patients with Advanced Non‐small Cell Lung Cancer (2025 Edition)

AGING MEDICINE, EarlyView.
The literature screening process and the 78 included studies in this article comprise 11 retrospective analyses, 14 prospective studies targeting geriatric patients, 33 prospective studies containing elderly subgroup analyses, 7 cohort studies/others, and 13 review articles. ABSTRACT Immune checkpoint inhibitors (ICIs) are an important treatment option
National Center of Gerontology, Lung Cancer Committee of Beijing Oncology Association, Editorial Board of Chinese Journal of Geriatrics, Li Lin, Nie Xin, Wei Qian, Li Xu, Tian Yumeng, Wu Lin, Wang Jingyi, Wang Zhijie, Wang Mingzhao, Cao Baoshan, Gu Yangchun, Huang Meijuan, Yu Min, Yang Bo, Song Qi   +17 more
wiley   +1 more source

The Evolution of Symptoms in Prodromal Dementia With Lewy Bodies: A Naturalistic History Study in a Chinese Memory Clinic

AGING MEDICINE, EarlyView.
The study characterized the evolution of symptoms prior to a diagnosis of DLB in people attending a Chinese memory clinic. Anxiety was the earliest recognized individual psychiatric symptom of DLB, followed by depression and memory decline. ABSTRACT Objectives Given that DLB is the second most common neurodegenerative dementia and early detection is ...
Ming Zhang, Tao Li, Dag Aarsland, Xiaozhen Lv, Jing Wang, Teng Xie, Xin Yu, Huali Wang   +7 more
wiley   +1 more source