Results 101 to 110 of about 8,225,712 (346)

The GLP1R Agonist Semaglutide Inhibits Reactive Astrocytes and Enhances the Efficacy of Neural Stem Cell Transplantation Therapy in Parkinson's Disease Mice

open access: yesAdvanced Science, EarlyView.
Compared to transplantation of neural stem cells (NSCs) alone, the combined treatment of NSCs with semaglutide more effectively improves motor dysfunction in Parkinson's disease (PD) mice. This synergistic effect may result from semaglutide's ability to suppress microglial activation, thereby preventing the transformation of resting astrocytes into ...
Dan Song   +6 more
wiley   +1 more source

Logical model of Personality and Cognition with possible Applications [PDF]

open access: yes, 2016
Although the cognition is significant in strategic reasoning, its role has been weakly analyzed, because only the average intelligence is usually considered.
Brada, Miro
core  

Regular versus Irregular Exercise Differentially Modulates Hippocampal‐Hepatic Acetylcholine Flux to Coordinate Fear Memory Extinction and Liver Inflammation

open access: yesAdvanced Science, EarlyView.
Ma et al. report the hippocampal and hepatic acetylcholine (ACh) levels are differently modulated by regular versus irregular exercise, which contributes to coordinate hippocampal astrocyte activity and hepatic FBXL6high neutrophil recruitment. This ACh‐modulated brain‐liver circuit links the effects of exercise on fear memory extinction and liver ...
Pengjiao Ma   +10 more
wiley   +1 more source

Applied folk in the troubled context of Genetic Psychology [PDF]

open access: yes, 2011
У статті здійснена спроба дослідити процес розвитку прикладної народної творчості у контексті генетичної психології (за С.Д.Максименком). Розглянуто аспекти «генетичної психології», проведено паралелі з розвитком народно-прикладної творчості.
Сабол, Діана Михайлівна
core   +1 more source

Single‐Cell Transcriptome Analysis Reveals That Hmga2 Regulates Neuroinflammation and Retinal Function by Modulating Müller Cell Autophagy Through PI3K/AKT Signaling Following MCAO‐Induced Retinal Ischemia

open access: yesAdvanced Science, EarlyView.
Employing snRNA‐seq post‐MCAO‐induced retinal ischemia (RI), this study revealed a novel Hmga2‐high Müller cell subpopulation. Hmga2 knockout alleviated neuroinflammation and RI symptoms, potentially by binding PI3K and regulating Müller cell autophagy.
Weihao Lv   +11 more
wiley   +1 more source

Counterbalancing O‐GlcNAcylation and STAT3 Phosphorylation in Ventral Tegmental Area Dopaminergic Neurons Mediates Behavioral Adaptations to Acute Restraint Stress

open access: yesAdvanced Science, EarlyView.
Acute restraint stress enhances STAT3Ser727 phosphorylation in dopaminergic neurons in mice. This modification promotes the upregulation of GABBR2 and GABRB3, reduces neuronal activity, and contributes to anxiety‐like behavior and diminished reward‐seeking following stress exposure.
Mingshuo Shao   +10 more
wiley   +1 more source

Beyond Theoretical Orientations: The Emergence of a Unified Scientific Framework in Professional Psychology [PDF]

open access: yes, 2013
Psychology has been remarkably successful as both a basic and applied science despite serious and persistent conflict between its many theoretical camps and schools of thought.
Melchert, Timothy P.
core   +1 more source

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