Results 181 to 190 of about 2,856,816 (301)

Developing a programme theory of a complex, home-based rehabilitation intervention for recovery after an episode of delirium. [PDF]

PLoS One
Raghuraman S, Morgan-Trimmer S, Anderson R, Goodwin VA, Clare L, Richards E, Bingham A, Goodwin E, Harwood R, Hawton A, Mahmoud A, Richardson SJ, Um J, Ukoumunne OC, Allan L.   +14 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

"<i>With all your friends in your pocket</i>" - a qualitative study about adolescents' experiences with social media from a health-promoting perspective. [PDF]

Int J Qual Stud Health Well-being
Ytrearne TV, Hella RT, Hjetland GJ, Skogen JC, Langeland E.   +4 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Psychosocial hierarchies of modifiable risk for Alzheimer's disease: A networks analysis. [PDF]

PLoS One
Brady JJR, Bartlett L, Roccati E, Norris K, Vickers JC, Sinclair D.   +5 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

The potential effects of hypothetical PM2.5 interventions on childhood autism in different neighborhood socioeconomic contexts. [PDF]

Am J Epidemiol
Yu X, Rahman MM, Lin JC, Chow T, Lurmann FW, Chen JC, Martinez MP, Schwartz J, Eckel SP, Chen Z, McConnell R, Hackman DA, Xiang AH, Garcia E.   +13 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Bayesian Mixed Models Approach to Exploring Resilience: Impact of Stress on Subjective Health and Affects Over Time During the COVID-19 Pandemic. [PDF]

Int J Methods Psychiatr Res
Schepers M, Schmidtmann I, Schäfer SK, Yilmaz S, Baumkötter R, Hartmann A, Petersen J, Hettich-Damm N, Wild P, Zahn D, Wollschläger D.   +10 more
europepmc   +1 more source